Abstract：【Objective】To investigate the association of plasma Fetuin-A to acute myocardial infarction (AMI) amongst the Chinese Han nationality in Changwu District, Jiangsu. 【Methods】 The ELISA method was used to detect plasma Fetuin-A in two groups with 86 cases of AMI patients (observation group) and 45 subjects without coronary artery disease (control group). 【Results】The plasma Fetuin-A in AMI patients (426.14±133.27g/L) was significantly higher than that in the control group (278.02±137.10g/L). The difference was statistical significance (P<0.01). After Logistic regression analysis with CAD (coronary artery disease) correction of risk factors (age, gender, cigarette, hypertension and diabetes). Linear regression analysis showed that only age in the traditional risk factors for coronary heart disease had a relation to plasma Fetuin-A (P<0.05). 【Conclusion】Plasma Fetuin-A is related to AMI risks.
[1] 罗贵全, 黄刚, 唐川苏, 等. 急性心肌梗死患者高敏C反应蛋白浓度变化及阿托伐他汀的干预效应[J].中西医结合心脑血管病杂志, 2013, 11(09): 1074-1075. [2] Judit, Cubedo, Teresa,et al. Coordinated proteomic signature changes in immune response and complement proteins in acute myocardial infarction: the implication of serum amyloid P-component [J].Int J Cardiol,2013, 168(6): 5196-5204. [3] Chen MS.Highlights of the 2002 update to 2000 American College of Cardiology/American Heart Association acute coronary syndrome guidelines [J].Cardio Rev,2003, 11(3): 113-121. [4] Ramesh, Ramasamy, Sathish Babu, et al. The prospect of serum magnesium and an electrolyte panel as an adjuvant cardiac biomarker in the management of acute myocardial infarction [J].J Clin Diagnostic Res:JCDR,2013, 7(5): 817-820. [5] 郑刚.胎球蛋白A在心血管病诊治中的应用前景 [J].中华临床医师杂志(电子版),2013, 13:6069-6071. [6] Fisher E, Stefan N, Saar K, et al. Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study [J].Circ Cardiovasc Genet,2009, 2(6): 607-613. [7] Roos M, von Eynatten M, Heemann U, et al. Serum fetuin-A, cardiovascular risk factors, and six-year follow-up outcome in patients with coronary heart disease [J].Am J Cardiol,2010, 105(12): 1666-1672.
2017, Vol. 34 
