耳针联合疏肝利胆汤加减对腹腔镜胆囊切除术患者氧化应激指标、炎症反应及疼痛水平的影响

doi:10.3969/j.issn.1671-7171.2023.11.023

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摘要【目的】探讨疏肝利胆汤加减联合耳针对腹腔镜胆囊切除术患者疼痛水平、炎症反应、氧化应激反应的影响。【方法】选择2019年1月至2022年7月本院收治的102例行腹腔镜胆囊切除术的患者,采用随机数字表法将其分为对照组与观察组,每组51例。对照组接受耳针治疗,观察组在对照组的基础上给予疏肝利胆汤治疗。比较两组术后相关指标、视觉模拟评分(VAS)及血清白介素-1β(IL-1β)、白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平,比较两组患者术后并发症发生情况。【结果】观察组术后首次下床时间、恢复进食时间、术后首次排便时间、术后首次排气时间短于对照组(P<0.05)。两组患者术后5 d的VAS均低于术后1 d,且观察组低于对照组(P<0.05)。术后5 d,两组血清TNF-α、CRP、IL-6、IL-1β水平低于术前1 d,IL-10水平高于术前1 d,且观察组上述指标与对照组比较,差异均有统计学意义(P<0.05);两组血清SOD、GSH-Px水平均低于术前1 d,差异有统计学意义(P<0.05),但观察组与对照组比较,差异无统计学意义(P>0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。【结论】对行腔镜胆囊切除术的患者术后采用疏肝利胆汤加减联合耳针治疗,可促进患者术后康复,减轻患者术后氧化应激反应及炎症反应,有效缓解疼痛,安全可靠。

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	万雪姣
	郝丹丹

关键词 ：胆囊切除术,腹腔镜, 疼痛, 炎症趋化因子类, 氧化性应激

Abstract：【Objective】To explore the effect of modified Shugan Lidan Tang combined with auricular acupuncture on pain level,inflammatory response,and oxidative stress response in patients undergoing laparoscopic cholecystectomy. 【Methods】A total of 102 patients undergoing laparoscopic cholecystectomy from January 2019 to July 2022 were selected and randomly divided into a control group and an observation group using a random number table method,with 51 cases in each group. The control group received auricular acupuncture treatment,while the observation group received modified Shugan Lidan Tang in addition to the control group. The relevant indicators,visual analog scale(VAS),serum interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor alpha(TNF-α),C-reactive protein(CRP),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) levels were compared between the two groups,and the incidence of postoperative complications was compared between the two groups.【Results】The time of first getting out of bed,the time of resuming eating,the time of first defecation,and the time of first exhaust after surgery were shorter in the observation group than in the control group(P<0.05). The VAS of both groups on day 5 after surgery was lower than that on day 1 after surgery,and the observation group was lower than the control group(P<0.05). On day 5 after surgery,the levels of serum TNF-α,CRP,IL-6,IL-1β in both groups were lower than those on day 1 before surgery,and the level of IL-10 was higher than that on day 1 before surgery.Compared with the control group,the above indicators in the observation group showed significant differences(P<0.05). The levels of serum SOD and GSH-Px in both groups were lower than those on day 1 before surgery,and the difference was statistically significant(P<0.05),but there was no significant difference between the observation group and the control group(P>0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05).【Conclusion】The use of modified Shugan Lidan Tang combined with auricular acupuncture in patients undergoing laparoscopic cholecystectomy can promote postoperative rehabilitation,alleviate postoperative oxidative stress response and inflammatory response,effectively alleviate pain,and is safe and reliable.

Key words： Cholecystectomy, Laparoscopic Pain Chemokines Oxidative Stress

收稿日期: 2023-05-18

中图分类号:

R657.4

通讯作者: * E-mail:127006296@qq.com

引用本文:

万雪姣, 郝丹丹. 耳针联合疏肝利胆汤加减对腹腔镜胆囊切除术患者氧化应激指标、炎症反应及疼痛水平的影响[J]. 医学临床研究, 2023, 40(11): 1693-1696.
WAN Xuejiao, HAO Dandan. Effects of Ear Acupuncture Combined with Shugan Lidan Tang on Oxidative Stress Index,Inflammatory Response and Pain Level in Patients after Laparoscopic Cholecystectomy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1693-1696.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.11.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I11/1693

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