Abstract：【Objective】To explore the value of acupoint injection of neostigmine in the rapid recovery management of patients undergoing gastric cancer laparoscopic radical surgery. 【Methods】Eighty patients undergoing gastric cancer laparoscopic radical surgery were randomly divided into two groups, with 40 patients in each group. The observation group received acupoint injection of neostigmine in addition to Fast Track Surgery (FTS) management during the perioperative period, while the control group received only FTS management during the perioperative period. Surgical-related indicators, serum levels of C-reactive protein (CRP) and albumin (ALB) at different time points, T lymphocyte level, incidence of adverse reactions, and 12-month survival rate were compared between the two groups. 【Results】The time of getting out of bed, the time of anal exhaust, the time of the first oral liquid diet, and the hospital stay in the observation group were significantly shorter than those in the control group (P<0.05). Compared to preoperative level, serum CRP level was significantly higher, while serum ALB level was significantly lower at 1 day and 3 days after surgery in both groups (P<0.05). The serum CRP level of the two groups at 3 days after surgery were significantly lower than those at 1 day after surgery, and ALB level at 3 days after surgery were significantly higher than those at 1 day after surgery in both groups (P<0.05). The observation group had significantly lower serum CRP level and significantly higher serum ALB level at different time points, if compared to the control group (P<0.05). CD3+, CD4+, and CD8+ levels at 3 days after surgery were significantly lower than preoperative level in both groups (P<0.05). The CD4+/CD8+ at 3 days after surgery showed no significant difference compared to preoperative level in the same group (P>0.05). The levels of CD3+, CD4+, CD8+, and CD4+/CD8+ at 3 days after surgery in the observation group were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions was significantly lower in the observation group compared to the control group (P<0.05). There was no significant difference in the 12-month survival rate between the two groups (P>0.05). 【Conclusion】Adding acupoint injection of neostigmine to FTS management can facilitate faster recovery, reduce the body's stress response, improve nutritional status, regulate immune function, and reduce the incidence of adverse reactions in patients after laparoscopic gastric cancer radical surgery.
张浩, 张熹玮, 蒋海锋, 刘岗. 穴位注射新斯的明用于胃癌腹腔镜根治术后快速康复管理中的价值[J]. 医学临床研究, 2023, 40(7): 979-983.
ZHANG Hao, ZHANG Xi-wei, JIANG Hai-feng, et al. Value of Acupoint Injection of Neostigmine in the Rapid Recovery Management of Gastric Cancer Laparoscopic Radical Surgery. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 979-983.
2023, Vol. 40 
