Abstract:【Objective】To explore the related influencing factors of postoperative incisional infection after laparoscopic cholecystectomy (LC).【Methods】A retrospective analysis of 80 patients treated with LC in our hospital from April 2020 to April 2022. Patients were divided into the incision infection group (n=20) and the incision non-infection group (n=60) based on whether postoperative incision infection occurred. General data of patients in the incision infection group were compared to those in the incision non-infection group. Logistic multiple regression analysis was then performed on single factors with statistical significance, and the receiver operating characteristic (ROC) curve was used to analyze the clinical value of relevant influencing factors in predicting postoperative incisional infection after LC.【Results】The proportion of patients with incision infection in terms of age >55 years old, surgery time>60 minutes, emergency surgery, and gallbladder rupture in the incision infection group was significantly higher than that in the incision non-infection group; and the difference was statistically significant (P<0.05). The results of logistic multiple regression analysis showed that surgical time, emergency surgery, and gallbladder rupture were the influencing factors of incision infection after LC surgery (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of surgical time, emergency surgery, and gallbladder rupture for predicting incision infection after LC surgery were 0.758, 0.733, and 0.808, respectively. While their Youden Index was 0.467, 0.441, and 0.617, respectively. 【Conclusion】The risk factors for incision infection during laparoscopic cholecystectomy are the operation time,emergency surgery and gallbladder rupture. Clinically, targeted treatment plans need to be formulated for such patients.