Abstract：【Objective】To explore the clinical significance of changes in serum helper T cell subsets (Th1/Th2) related cytokines in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with allergic rhinitis. 【Methods】A total of 105 OSAHS patients who admitted to the hospital from October 2019 to January 2021 were selected for the study,and 94 healthy volunteers who came to the hospital for physical examination during the same period were selected. The levels of serum interferon-γ (IFN-γ),interleukin-2 (IL-2),interleukin-4 (IL-4) and interleukin-13 (IL-13) in OSAHS patients and healthy individuals were measured and compared. As the situation of OSAHS with allergic rhinitis was considered,the factors affecting OSAHS patients with allergic rhinitis was analyzed. Thus,the value of serum IFN-γ,IL-2,IL-4,and IL-13 levels in predicting OSAHS patients with allergic rhinitis was investigated. 【Results】Serum levels of both IFN-γ and IL-2 in OSAHS patients were lower than those in healthy people (P<0.05),and serum IL-4 and IL-13 levels were higher than those in healthy people (P<0.05). The levels of serum IFN-γ and IL-2 in patients with allergic rhinitis were lower than those without allergic rhinitis group (P<0.05),while the levels of serum IL-4 and IL-13 were higher than those without allergic rhinitis group (P<0.05). Compared to OSAHS patients without allergic rhinitis,the composition ratio of the apnea/hypopnea classification and pathological adenoid hypertrophy in patients with allergic rhinitis were significantly different (P<0.05).The levels of IFN-γ,IL-2,IL-4,IL-13 and pathological adenoid hypertrophy were related factors affecting OSAHS patients with allergic rhinitis (P<0.05). The area under the curve (AUC) of serum IFN-γ,IL-2,IL-4 and IL-13 levels in predicting OSAHS patients with allergic rhinitis were 0.846,0.768,0.778,and 0.853,respectively. 【Conclusion】Clinical detection of serum IFN-γ,IL-2,IL-4,and IL-13 levels can be used as sensitive indicators to predict OSAHS patients with allergic rhinitis.
何海燕, 徐健, 顾晓静, 徐永生. Th1/Th2相关细胞因子在OSAHS合并变应性鼻炎患者血清中的表达水平及其意义[J]. 医学临床研究, 2023, 40(5): 741-743.
HE Hai-yan, XU Jian, GU Xiao-jing, et al. Clinical Significance in Detecting Serum Changes of Th1/Th2 Related Cytokines in OSAHS Patients with Allergic Rhinitis. JOURNAL OF CLINICAL RESEARCH, 2023, 40(5): 741-743.
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2023, Vol. 40 
