Abstract：【Objective】To explore the analgesic effect of balanced analgesia with sufentanil and flurbiprofen axetil on postoperative pain after cervical cancer surgery. 【Methods】A total of 130 patients with cervical cancer who underwent surgical treatment in our hospital were randomly divided into two groups with 65 cases in each group. The observation group was treated with sufentanil and flurbiprofen axetil, while patients in the control group received sufentanil only for postoperative analgesia. Pain scores (VAS) at different time points after surgery, postoperative intravenous analgesia pump (PCIA) compressions, serum prostaglandin E2 (PGE2), cortisol (Cor), beta endorphin (β-EP), and serotonin (5-HT) levels were compared between the two groups. 【Results】During 12-48h after operation, the VAS scores of the observation group were lower than those of the control group, and the differences between the two groups were significant (P<0.05). At 24 and 48 hours after surgery, the total number of PCIA compressions in the observation group was lower than that in the control group (P<0.05). There were no significant differences in serum PGE2, 5-HT, Cor and β-EP levels between the two groups before surgery (P>0.05). The levels of serum PGE2, 5-HT, Cor and β-EP in the observation group at 24 hours after operation were lower than those in the control group (P<0.05). 【Conclusion】The balanced analgesia of sufentanil and flurbiprofen has a better analgesic effect after cervical cancer surgery, which can effectively reduce the secretion of postoperative pain related factors.
韩琪, 李凤玲, 陈惠群, 廖永强, 谢海辉. 舒芬太尼与氟比洛芬酯平衡镇痛对宫颈癌开腹手术患者术后的镇痛效果[J]. 医学临床研究, 2020, 37(11): 1644-1646.
HAN Qi, LI Feng-ling, CHEN Hui-qun, et al. Analgesic Effect of Balanced Analgesia with Sufentanil and Flurbiprofen on Postoperative Pain in Patients Undergoing Cervical Cancer Surgery. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1644-1646.
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2020, Vol. 37 
