Abstract：【Objective】To observe the effect of probiotics on intestinal flora in elderly patients with abdominal trauma combined with liver injury. 【Methods】A total of 116 elderly patients with abdominal trauma combined with liver injury were randomly divided into the observation group and the control group, with 58 patients in each group. The patients in both groups received surgical treatment such as drainage, ligation or partial resection according to the situation of abdominal trauma and routine perioperative therapy. The patients in the control group were treated with artificial liver support system on this basis, while the patients in the observation group were treated with probiotics on this basis, To compare the clinical efficacy of the two groups of patients after treatment, to compare the levels of various indicators of liver function [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), albumin (ALB)], and the number of intestinal flora (Escherichia coli, bifidobacteria, lactobacillus, staphylococcus) of the two groups of patients before and after treatment, and to count and record the occurrence of postoperative complications of the two groups of patients during treatment. 【Results】The total effective rate of the observation group after treatment was 84.48%, which was significantly higher than that of the control group (65.52%), with a statistically significant difference (P<0.05). After treatment, ALT, AST and TBIL of the two groups were significantly lower than that before treatment, and ALB was significantly higher than that before treatment, with a statistically significant difference (P<0.05); After treatment, ALT, AST and TBIL in the observation group were significantly lower than those in the control group, and ALB was significantly higher than those in the control group, with a statistically significant difference (P<0.05). After treatment, the number of Escherichia coli and Staphylococcus in the two groups was significantly lower than that before treatment, and the number of Bifidobacterium and Lactobacillus was significantly higher than that before treatment (P<0.05); After treatment, the number of Escherichia coli and Staphylococcus in the observation group was significantly lower than that in the control group, and the number of Bifidobacterium and Lactobacillus was significantly higher than that in the control group (P<0.05). There was no significant difference in the total incidence of postoperative complications between the two groups after treatment (P>0.05). 【Conclusion】Probiotic adjuvant therapy can significantly improve the efficacy of elderly patients with abdominal trauma combined with liver injury, can significantly improve the liver function of patients, regulate intestinal flora, and is safe to use, which is worthy of clinical promotion.
王铭, 黎冬梅, 王宁宁, 高庆剑. 益生菌辅助治疗老年腹部外伤合并肝损伤患者的临床疗效及其对患者肠道菌群的影响[J]. 医学临床研究, 2022, 39(12): 1862-1865.
WANG Ming, LI Dong-mei, WANG Ning-ning, et al. Effect of Probiotics on Intestinal Flora in Elderly Patients with Abdominal Trauma and Liver Injury. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1862-1865.
2022, Vol. 39 
