老年脑卒中偏瘫患者继发骨质疏松的危险因素分析

doi:10.3969/j.issn.1671-7171.2022.05.006

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摘要【目的】探讨老年脑卒中偏瘫患者继发骨质疏松的危险因素。【方法】回顾性分析本院2018年1月至2021年1月收治的60例老年脑卒中偏瘫患者的临床资料。根据是否继发骨质疏松分为发生组、未发生组,统计两组患者年龄、病程、性别、体重指数(BMI)、合并疾病、受累循环部分、同型半胱氨酸(Hcy)、血压[收缩压(SBP)、舒张压(DBP)]、血脂[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)]、凝血指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、D-二聚体(DD)]等临床相关资料,多因素Logistic回归分析法分析患者继发骨质疏松的危险因素。【结果】60例老年脑卒中偏瘫患者中,有26例(43.34%)患者继发骨质疏松,纳为发生组;其余34例(56.66%)未发生,纳为未发生组。两组患者年龄、病程、BMI、血压、血脂、凝血指标比较差异均无统计学意义(P>0.05)。发生组女性、高血压、单侧前循环多发梗死所占比及LDL-C、Hcy水平均高于未发生组(P<0.05)。多因素Logistic回归分析显示,性别(OR=3.421,95%CI=2.011～6.087)、受累循环部分(OR=3.809,95%CI=1.792～7.326)、高血压(OR=2.187,95%CI=1.126～1.987)、LDL-C(OR=0.968,95%CI=0.621～3.874)、Hcy(OR=4.932,95%CI=2.154～6.514)是影响老年脑卒中偏瘫患者继发骨质疏松的独立危险因素(P<0.05)。【结论】性别、高血压、受累循环部分、LDL-C及Hcy是老年脑卒中偏瘫患者继发骨质疏松的危险因素。

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	王立新
	李庆芬
	高俊
	杨聪慧

关键词 ：卒中/并发症, 偏瘫/并发症, 骨质疏松/并发症, 老年人, 危险因素

Abstract：【Objective】 To investigate the influencing factors of secondary osteoporosis in elderly stroke patients with hemiplegia. 【Methods】 The clinical data of 60 elderly stroke patients with hemiplegia who were admitted to our hospital from January 2018 to January 2021 were retrospectively analyzed. According to whether there was secondary osteoporosis, they were divided into the occurrence group and the non-occurrence group. The age, course of disease, gender, body mass index (BMI), co-morbidities, involved circulatory part, homocysteine (Hcy), blood pressure [Systolic blood pressure (SBP), diastolic blood pressure (DBP)], blood lipids [high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), total cholesterol (TC)], coagulation indexes [prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), D-dimer (DD)] and other clinical related data of the two groups of patients were compared. Multivariate logistic regression was used to analyze the risk factors for secondary osteoporosis in patients. 【Results】 Among the 60 elderly stroke patients with hemiplegia, 26 (43.34%) patients had secondary osteoporosis, and they were classified as the occurrence group; the remaining 34 cases (56.66%) did not occur, and they were classified as the non-occurrence group. There were no significant differences in age, course of disease, BMI, blood pressure, blood lipids, and coagulation indexes between the two groups (P>0.05). The proportion of women, hypertension, multiple infarctions of unilateral anterior circulation, LDL-C and Hcy levels in the occurrence group were higher than those in the non-occurrence group (P<0.05). Multivariate Logistic regression analysis showed that gender (OR=3.421, 95%CI=2.011~6.087), involved circulation (OR=3.809, 95%CI=1.792~7.326), hypertension (OR=2.187, 95%CI=1.126～1.987), LDL-C(OR=0.968, 95%CI=0.621～3.874), Hcy (OR=4.932, 95%CI=2.154～6.514) were independent risk factors for secondary osteoporosis in elderly stroke patients with hemiplegia (P<0.05). 【Conclusion】 Gender, hypertension, involved circulatory fraction, LDL-C and Hcy are risk factors for secondary osteoporosis in elderly stroke patients with hemiplegia.

Key words： Stroke /CO Hemiplegia/CO Osteoporosis/CO Aged Risk Factors

收稿日期: 2022-01-24

中图分类号:

R743.3

基金资助:江苏省级重点研发计划(社会发展)项目(编号: BE2019653)

通讯作者: **E-mail: wxd3974@163.com

引用本文:

王立新, 李庆芬, 高俊, 杨聪慧. 老年脑卒中偏瘫患者继发骨质疏松的危险因素分析[J]. 医学临床研究, 2022, 39(5): 660-663.
WANG Li-xin, LI Qing-fen, GAO Jun, et al. Analysis of Risk Factors for Secondary Osteoporosis in Elderly Stroke Patients with Hemiplegia. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 660-663.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.05.006 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I5/660