Abstract：【Objective】To investigate the effects of folic acid (FA) supplementation before and after pregnancy on blood pressure,serum levels of homocysteine (HCY) and vitamin B12 (VitB12) in pregnant women.【Methods】A total of 320 expectant pregnant women who were admitted to Weinan Central Hospital from March 2018 to March 2022 were selected. According to the timing of low dose FA supplementation,the patients were divided into pre-pregnancy supplementation group (group A,n=100 cases) and post-pregnancy supplementation group (group B,n=220 cases). The baseline data of the two groups were compared,including initial labor,planned pregnancy,pregnancy habits (non-drinking,non-smoking and non-drinking tea),FA supplemental dose and the distribution of time to end supplementation. Serum HCY,VitB12 and FA levels,incidence of hypertensive diseases during pregnancy,prenatal and postnatal systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were analyzed. Pearson correlation analysis among serum levels of VitB12,HCY and FA was performed; And the correlation between the above serum indexes and the blood pressure of prenatal and postnatal pregnant women was analyzed.【Results】There was no significant difference in baseline data such as initial labor,planned pregnancy,pregnancy habits,FA dosage and time to end supplementation between the pre-pregnancy supplementation group and the post-pregnancy supplementation group (P>0.05).The serum FA level in pre-pregnancy supplementation group was significantly higher than that in post-pregnancy supplementation group (P<0.05). However,the serum HCY and VitB12 levels were not statistically significant in both pre-pregnant and post-pregnant supplementation groups (P>0.05).Serum VitB12 level was negatively correlated with serum HCY level (r=-0.143,P<0.05); Serum VitB12 level was positively correlated with serum FA level (r=0.254,P<0.05); Serum HCY level was negatively correlated with serum FA level (r=-0.318,P<0.05). The incidence of pregnancy-induced hypertension was 4.00% in the pre-pregnancy group and 3.64% in the post-pregnancy group,which was no significant difference between the two groups (P>0.05). Before delivery,there were no significant differences in SBP and DBP between the two groups (P>0.05); After delivery,SBP and DBP were significantly decreased in the two groups,if compared to the prenatal situation (P<0.05),but there were no statistical differences between the two groups (P>0.05). There was no significant relationship of serum VitB12,HCY and FA levels with prenatal and postpartum blood pressure (P>0.05).【Conclusion】Compared to the supplementation of low dose FA after pregnancy,the supplementation of low dose FA before pregnancy has no significant effect on the risk of hypertension,blood pressure,serum HCY and VitB12 levels,which is worthy of clinical verification.
刘佳璐, 赵瑾. 孕前及孕后补充小剂量叶酸对孕妇血压及血清HCY、VitB12水平的影响[J]. 医学临床研究, 2022, 39(12): 1837-1840.
LIU Jia-lu, ZHAO Jin. Effects of Folic Acid Supplementation before and after Pregnancy on Blood Pressure,Serum HCY and VitB12 Levels in Pregnant Women. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1837-1840.
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2022, Vol. 39 
