高血压合并慢性肾脏病患者与单纯高血压患者临床特征比较

doi:10.3969/j.issn.1671-7171.2022.04.017

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摘要【目的】比较高血压合并慢性肾脏病患者与单纯高血压患者的临床特征。【方法】两院收治的高血压合并慢性肾脏病患者共40例作为观察组,另选择单纯高血压患者40例为对照组。监测并比较两组患者血压参数[日间收缩压(SBP)、夜间SBP、全天SBP平均值、日间舒张压(DBP)、夜间DBP、全天DBP平均值]、血压变异性、血压负荷值的差异。比较两组患者的血压类型及心率变异性指标[R-R间期所有窦性心搏的标准差(SDNN)、N-N间期每5 min平均值的标准差(SDANN)、相邻两N-N间期之差的平方根(rMSSD)、相邻两R-R间期差值＞50 ms的心搏数在总数中的占比(PNN50)]。【结果】观察组夜间SBP、夜间DBP均高于对照组,且差异有统计学意义(P<0.05)。观察组各时间段的SBP、DBP变异性均高于对照组(P<0.05)。观察组夜间SBP负荷值、夜间DBP负荷值高于对照组(P<0.05)。观察组非杓型血压比例显著高于对照组,反杓型血压比例显著低于对照组,且两组之间相比较差异均有统计学意义(P<0.05)。观察组的SDNN、SDANN、rMSSD、PNN50均低于对照组(P<0.05)。【结论】高血压合并慢性肾脏病患者的夜间血压参数、负荷值较高,血压节律、血压变异性、心率变异性均有别于单纯高血压患者,可以此为参照对高血压合并慢性肾脏病患者进行相应治疗。

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	王瑞娟
	张楠

关键词 ：高血压/并发症, 肾疾病/并发症, 慢性病

Abstract：【Objective】To observe the clinical characteristics of hypertension with chronic kidney disease and simple hypertension.【Methods】A total of 40 patients with hypertension complicated with chronic kidney disease in our hospital were selected as the observation group, and 40 patients with simple hypertension were selected as the control group.The blood pressure parameters, blood pressure variability and blood pressure load value of all patients [daytime systolic blood pressure (SBP), nighttime SBP, 24h average value of SBP, daytime diastolic blood pressure (DBP), nighttime DBP and 24h average value of DBP], the blood pressure types and heart rate variability indexes of the two groups were measured and compared between the two groups[standard deviation of all sinus beats in R-R interval (SDNN), standard deviation of the average value of N-N interval every 5 minutes (SDANN), square root of the difference between two adjacent N-N intervals (RMSSD), and the proportion of heart beats with the difference between two adjacent R-R intervals >50 ms in the total number (pNN50)].【Results】The SBP and DBP at night in the observation group were higher than those in the control group(P<0.05).The variability of SBP and DBP in the observation group was higher than that in the control group(P<0.05).The night SBP load value and night DBP load value of the observation group were higher than those of the control group (P<0.05).The number of non-dipper blood pressure cases in the observation group was significantly higher than that in the control group, and the number of reverse dipper blood pressure cases in the observation group was significantly lower than that in the control group(P<0.05).The SDNN, SDANN, RMSSD and PNN50 of the observation group were lower than those of the control group(P<0.05).【Conclusion】Blood pressure parameters, load values at night, blood pressure rhythm, blood pressure variability, heart rate variability of hypertension patients with chronic kidney disease are all different from essential hypertension, which can be used as a reference for the corresponding treatment of patients with hypertension and chronic kidney disease.

Key words： Hypertension/CO Kidney Diseases/CO Chronic Disease

收稿日期: 2021-11-20

中图分类号:

R692.023

引用本文:

王瑞娟, 张楠. 高血压合并慢性肾脏病患者与单纯高血压患者临床特征比较[J]. 医学临床研究, 2022, 39(4): 539-541.
WANG Rui-juan, ZHANG Nan. Comparison of Clinical Characteristics between Patients with Hypertension Complicated with Chronic Kidney Disease and Patients with Simple Hypertension. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 539-541.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.04.017 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I4/539

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