妊娠晚期脐动脉血流参数及血清SP1与胎儿脐带绕颈程度的相关性分析

doi:10.3969/j.issn.1671-7171.2022.10.022

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摘要【目的】探讨妊娠晚期脐动脉收缩期最大血流速度/舒张末期最大血流速度(S/D)、搏动指数(PI)、阻力指数(RI)及血清妊娠特异性β₁糖蛋白(SP1)与胎儿脐带绕颈程度的关系。【方法】选取2019年2月至2020年5月在宜川县人民医院接受产前超声检查且胎儿脐带绕颈发生1周的90例妊娠晚期孕妇(观察组),另外,选取同期在宜川县人民医院接受产前超声检查的100例健康孕妇(对照组)。比较两组胎儿脐带绕颈压迹深度及脐动脉S/D、PI、RI和血清SP1水平;采用Pearson分析观察组孕妇脐动脉血流参数、血清SP1水平与胎儿脐带绕颈压迹深度的相关性。【结果】与对照组比较,观察组孕妇脐动脉S/D、PI、RI显著升高(P<0.05),血清SP1水平显著降低(P<0.05);胎儿脐带绕颈压迹深度＜0.60 cm、0.60～0.79 cm、≥0.80 cm孕妇脐动脉S/D、PI、RI依次升高(P<0.05),血清SP1水平依次降低(P<0.05)。观察组孕妇脐动脉S/D、PI、RI与脐带绕颈压迹深度呈显著正相关(r=0.587、0.529、0.657,P<0.05),血清SP1水平与脐带绕颈压迹深度呈显著负相关(r=-0.538,P<0.05)。【结论】胎儿脐带绕颈的妊娠晚期孕妇脐动脉S/D、PI、RI升高,血清SP1水平降低,均与胎儿脐带绕颈程度密切相关。

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	呼延芳

关键词 ：妊娠末期, 脐动脉, 血流速度, 脐带绕颈, 胎儿疾病

Abstract：【Objective】 To investigate the relationship between the maximum systolic/diastolic umbilical artery blood flow velocity (S/D), pulsatility index (PI), resistance index (RI) and serum pregnancy specificity β₁ glycoprotein (SP1) with the degree of umbilical cord around the neck. 【Methods】 From February 2019 to May 2020, 90 late pregnant women (observation group) who received prenatal ultrasound examination in the Yichuan County People's Hospital in Shaanxi Province and had fetal umbilical cord around the neck for one week were selected. In addition, 100 healthy pregnant women (control group) who received prenatal ultrasound examination in the Affiliated Hospital of Yan'an University in Shaanxi Province in the same period were selected. The depth of umbilical cord around neck impression, umbilical artery S/D, PI, RI and serum SP1 levels were compared between the two groups; Pearson was used to analyze the correlation between umbilical artery blood flow parameters, serum SP1 level and the depth of fetal umbilical cord around the neck indentation in the observation group. 【Results】 Compared with the control group, the umbilical artery S/D, PI, RI in the observation group were significantly increased (P<0.05), and the serum SP1 level was significantly decreased (P<0.05); When the depth of fetal umbilical cord around the neck indentation is less than 0.60 cm, 0.60～0.79 cm, ≥0.80 cm, the umbilical artery S/D, PI, RI of pregnant women increase in turn (P<0.05), and the serum SP1 level decreases in turn (P<0.05). The S/D, PI, RI of umbilical artery in the observation group were positively correlated with the depth of umbilical cord around the neck (r=0.587, 0.529, 0.657, P<0.05), and the serum SP1 level was negatively correlated with the depth of umbilical cord around the neck (r=-0.538, P<0.05). 【Conclusion】 The increase of S/D, PI, RI of umbilical artery and the decrease of serum SP1 level in late pregnancy women with fetal umbilical cord around the neck are closely related to the degree of fetal umbilical cord around the neck.

Key words： Pregnancy Trimester, Third Umbilical Arteries Blood Flow Velocity Nuchal Cord Fetal Diseases

收稿日期: 2021-12-06

中图分类号:

R714.43

引用本文:

呼延芳. 妊娠晚期脐动脉血流参数及血清SP1与胎儿脐带绕颈程度的相关性分析[J]. 医学临床研究, 2022, 39(10): 1520-1523.
HU Yan-fang. Correlation Analysis of Umbilical Artery Blood Flow Parameters and Serum SP1 with the Degree of Umbilical Cord around the Neck at Late Pregnancy. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1520-1523.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.10.022 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I10/1520

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