Abstract：【Objective】To investigate the effect of Zhenwu decoction combined with Xuefu Zhuyu decoction on cardiac function and ventricular remodeling in patients with chronic heart failure. 【Methods】A total of 120 patients with chronic heart failure admitted to our hospital from June 2018 to June 2021 were selected and randomly divided into observation group and control group with 60 patients in each group. The control group was treated with conventional western medicine, while the observation group was treated with Zhenwu decoction combined with Xuefu Zhuyu decoction on the basis of the control group. Compare the clinical efficacy of the two groups, record the TCM syndrome scores of the two groups, compare the left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular end diastolic thickness (PWD), left ventricular myocardial mass index (LVMI), left ventricular posterior wall thickness (LVPWT) of the two groups before and after treatment, and detect the serum aldosterone (ALD) Angiotensin Ⅱ (Ang Ⅱ) level and adverse reactions during treatment were recorded. 【Results】 The total clinical effective rate in the observation group was 88.33% (53/60), higher than that in the control group 75.00% (45/60), with a statistically significant difference (P<0.05). After treatment, the scores of main syndrome and secondary syndrome in the two groups were lower than those before treatment, and the scores in the observation group were lower than those in the control group, with a statistically significant difference (P<0.05); LVESD, LVEDD, PWD, LVMI, LVPWT of the two groups were lower than before treatment, LVEF was higher than before treatment, and the difference between the observation group and the control group was statistically significant (P<0.05); The levels of serum ALD and Ang Ⅱ in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 The Zhenwu decoction combined with the Xuefu Zhuyu decoction is effective in treating patients with chronic heart failure, which is beneficial to improve the clinical symptoms of patients with chest tightness, chest pain, palpitation, and better improve the cardiac function and ventricular remodeling of patients. It is safe and has popularization value.
向越, 付晓星. 真武汤合血府逐瘀汤对慢性心衰患者心功能及心室重构的影响[J]. 医学临床研究, 2022, 39(9): 1303-1306.
XIANG Yue, FU Xiao-xing. Effect of Zhenwu Decoction Combined with Xuefu Zhuyu Decoction on Cardiac Function and Ventricular Remodeling in Patients with Chronic Heart Failure. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1303-1306.
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