血清CER、GP73及肝脏硬度值与ATL轻度升高乙肝患者肝纤维化分期的相关性

doi:10.3969/j.issn.1671-7171.2022.09.015

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摘要【目的】探讨血清高尔基体蛋白73(GP73)、铜蓝蛋白(CER)及肝脏硬度值(LSM)与丙氨酸转氨酶(ATL)轻度升高的慢性乙型肝炎(CHB)患者肝纤维化分期的相关性。【方法】选取两院收治的CHB患者122例为观察组;另外选取同期体检且身体健康的100例志愿者为对照组。比较两组及不同肝纤维化分期CHB患者CER、GP73、LSM水平的差异。通过受试者工作特征(ROC)曲线及相关性分析明确CER、GP73、LSM诊断CHB的价值及其与肝纤维化分期的关系。【结果】观察组CER水平显著低于对照组(P<0.05);观察组GP73、LSM水平显著高于对照组(P<0.05)。经ROC曲线分析证实CER、GP73、LSM诊断CHB的曲线下面积分别为0.718、0.859、0.905(均P<0.05)。不同肝纤维化分期CHB患者CER比较,S₁期＞S₂期＞S₃期＞S₄期,且差异均有统计学意义(P<0.05);不同肝纤维化分期CHB患者GP73、LSM比较,S₁期＜S₂期＜S₃期＜S₄期,且差异均有统计学意义(P<0.05)。经相关性分析证实CER与CHB患者肝纤维分期呈负相关(P<0.05),GP73、LSM与CHB患者肝纤维分期呈正相关(均P<0.05)。【结论】ALT≤2×正常值上限(ULN)的 CHB患者CER显著降低,而GP73、LSM显著上升,其可用于疾病的诊断,且其水平变化与肝纤维化严重程度关系密切,值得临床关注。

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	李丹杰
	韦晓强

关键词 ：乙型肝炎,慢性, 丙氨酸转氨酶, 高尔基体基质蛋白质类, 血浆铜蓝蛋白

Abstract：【Objective】To investigate the correlation of serum golgi protein 73 (GP73),ceruloplasmin (CER) and liver stiffness/hardness (LSM) with liver fibrosis stage in chronic hepatitis B (CHB) patients with slightly elevated alanine aminotransferase (ATL).【Methods】A total of 122 CHB patients were selected as the observation group.In addition,100 healthy volunteers were selected as the control group.CER,GP73 and LSM levels were compared between the two groups.And levels of CER,GP73 and LSM were compared in CHB patients with different stages of liver fibrosis as well.The diagnostic value of CER,GP73 and LSM in CHB diagnosis and their relationship with liver fibrosis stage were determined by ROC and correlation analysis.【Results】The CER level in the observation group was significantly lower than that in the control group (P<0.05).The levels of GP73 and LSM in the observation group were significantly higher than those in the control group (P<0.05).ROC analysis confirmed that the areas under the curve of CER,GP73 and LSM for CHB diagnosis were 0.718,0.859 and 0.905,respectively (P<0.05).The value of CER in CHB patients with different stages of liver fibrosis was S₁>S₂>S₃>S₄,and the differences were statistically significant (P<0.05).While the levels of GP73 and LSM in CHB patients with different stages of liver fibrosis were S₁<S₂<S₃<S₄,and the differences were statistically significant (P<0.05).Correlation analysis confirmed that CER was negatively correlated with liver fiber staging in CHB patients,while GP73 and LSM were positively correlated with liver fiber staging in CHB patients (all P<0.05).【Conclusion】CER of CHB patients with ALT≤2× upper limit of normal value (ULN) decreased significantly,while GP73 and LSM increased significantly.Thus these changes can be used for disease diagnosis.They are closely related to the severity of liver fibrosis,which is worthy of clinical attention.

Key words： Hepatitis B,Chronic Alanine Transaminase Golgi Matrix Proteins Ceruloplasmin

收稿日期: 2022-04-10

中图分类号:

R512.62

通讯作者: *E-mail:weixiaoqiang1998@smmu.edu.cn

引用本文:

李丹杰, 韦晓强. 血清CER、GP73及肝脏硬度值与ATL轻度升高乙肝患者肝纤维化分期的相关性[J]. 医学临床研究, 2022, 39(9): 1332-1335.
LI Dan-jie, WEI Xiao-qiang. Correlation of CER,GP73 and Liver Hardness with Hepatic Fibrosis Stage in Chronic Hepatitis B Patients with Slightly Elevated ATL. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1332-1335.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.09.015 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I9/1332