医学临床研究
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医学临床研究  2022, Vol. 39 Issue (8): 1157-1160    DOI: 10.3969/j.issn.1671-7171.2022.08.011
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血清CRP、PCT、LDH、cys C水平与蜂螫伤后肾损伤的关系
陈尚扣, 黄仁春, 石善秋**
汉中市中心医院急诊医学科,陕西 汉中 723000
Relationship of Serum CRP,PCT,LDH and cys C Levels with Kidney Injury after Bee Sting
CHEN Shang-kou, HUANG Ren-chun, SHI Shan-qiu
Department of Emergency Medicine,Hanzhong Central Hospital,Hanzhong Shaanxi 723000
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摘要 【目的】探讨血清C反应蛋白(CRP)、降钙素原(PCT)、乳酸脱氢酶(LDH)、胱抑素C(cys C)水平与蜂螫伤后肾损伤的关系。【方法】回顾性分析130例蜂螫伤患者的临床资料,依据患者是否发生急性肾损伤(AKI)分为AKI组(n=38)与非AKI组(n=92)。在入院时收集两组患者的基线资料信息并行实验室指标[血小板计数(PLT)、CRP、PCT、LDH、cys C]检测。比较两组相关指标的差异,通过受试者工作特征曲线(ROC曲线)分析血清CRP、PCT、LDH、cys C预测蜂螫伤患者并发AKI的价值,并将两组有差异的信息纳入多因素Logistic回归分析,行量化赋值,明确蜂螫伤患者并发AKI的影响因素。【结果】两组性别、年龄、蜂螫伤部位、合并疾病、蜂螫伤时间及PLT水平相比较,差异无统计学意义(P>0.05)。AKI组胡蜂螫伤、伤后入院时间≥6 h占比显著高于非AKI组,血清CRP、PCT、LDH、cys C水平显著高于非AKI组,且差异均有统计学意义(P<0.05)。经ROC曲线分析显示,CRP≥6.285 mg/L、PCT≥1.570 ng/mL、LDH≥1482.175 U/L、cys C≥1.430 mg/L能够用于预测蜂螫伤患者并发AKI(P<0.05)。经多因素Logistic回归分析证实螫伤蜂种、伤后入院时间及血清CRP、PCT、LDH、cys C水平是蜂螫伤患者并发AKI的显著影响因素(P<0.05)。【结论】血清CRP、PCT、LDH及cys C水平是蜂螫伤患者并发AKI的显著影响因素,且CRP≥6.285 mg/L、PCT≥1.570 ng/mL、LDH≥1482.175 U/L、cys C≥1.430 mg/L可预测AKI的发生。
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陈尚扣
黄仁春
石善秋
关键词 咬伤和蜇伤肾/损伤C反应蛋白质/血液降钙素/血液L-乳酸脱氢酶/血液抑素类/血液    
Abstract:【Objective】To investigate the relationship of serum C-reactive protein (CRP),procalcitonin (PCT),lactate dehydrogenase (LDH) and cystatin C (cys C) levels with kidney injury after bee sting.【Methods】The clinical data of 130 patients with bee stings were retrospectively analyzed. According to whether acute kidney injury (AKI),patients were divided into the AKI group (n=38) and the non-AKI group (n=92).At admission,baseline information was collected and laboratory indicators [platelet count (PLT),CRP,PCT,LDH,cys C] were measured. The value of serum CRP,PCT,LDH and cys C in predicting AKI in patients with bee sting was analyzed by ROC. The difference information between the two groups was included in multivariate Logistic regression analysis and quantitative assignment was performed to identify the influencing factors of AKI in patients with bee sting.【Results】There were no significant differences in gender,age,bee sting site,associated diseases,bee sting time and PLT level between the two groups (P>0.05).The proportion of bee stings and hospital admission time≥6 h after injury in the AKI group was significantly higher than that in the non-AKI group,and the levels of serum CRP,PCT,LDH and cys C were significantly higher in the AKI group than those in the non-AKI group,with statistical significance (P<0.05).ROC analysis showed that CRP≥6.285 mg/L,PCT≥1.570 ng/mL,LDH≥1482.175 U/L and cys C≥1.430 mg/L could be used to predict AKI in bee sting patients (P<0.05).Multiple Logistic regression analysis confirmed that wasp species of sting,hospital admission time and serum levels of CRP,PCT,LDH and cys C were significant influencing factors of AKI in patients with bee sting injury (P<0.05).【Conclusion】Serum levels of CRP,PCT,LDH and cys C were significant influencing factors of AKI in bee sting patients. The occurrence of AKI can be predicted when CRP≥6.285 mg/L,PCT≥1.570 ng/mL,LDH≥1482.175 U/L and cys C≥1.430 mg/L showed up.
Key wordsBites and Stings    Bees    Kidney/IN    C-Reactive Protein/BL    Calcitonin/BL    L-Lactate Dehydrogenase/BL    Chalones/BL
收稿日期: 2022-04-11     
中图分类号:  R181.2  
基金资助:陕西省教育厅重点实验室科研计划项目(16JS027)
通讯作者: **E-mail:shishanqiu0588@163.com   
引用本文:   
陈尚扣, 黄仁春, 石善秋. 血清CRP、PCT、LDH、cys C水平与蜂螫伤后肾损伤的关系[J]. 医学临床研究, 2022, 39(8): 1157-1160.
CHEN Shang-kou, HUANG Ren-chun, SHI Shan-qiu. Relationship of Serum CRP,PCT,LDH and cys C Levels with Kidney Injury after Bee Sting. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1157-1160.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.08.011     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I8/1157
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