Abstract：【Objective】To investigate the relationship between blood pressure variability (BPV), heart rate variability(HRV) and acute kidney injury (AKI) in patients with essential hypertension and ST segment elevation myocardial infarction (STEMI). 【Methods】A total of 100 patients with primary hypertension complicated with STEMI in our hospital were selected as the research objects, and they were divided into AKI group (n=23) and non AKI group (n=77) according to whether AKI occurred during hospitalization. The 24 h systolic blood pressure variability (24hSBPR), 24 h diastolic blood pressure variability (24hDBPV), standard deviation of 24 h normal ECG RR interval (SDNN) and percentage of 24 h adjacent RR interval difference > 50 ms in total RR interval (PMN50) were compared between the two groups. The correlation between BPV, heart rate variability and AKI in patients with essential hypertension and STEMI was analyzed by logistic regression analysis. 【Results】There was no significant difference in age, gender, BMI, smoking, drinking, diabetes and dyslipidemia between the group AKI and the non AKI group (P>0.05). The SCR level at admission and the time from onset to emergency in the AKI group were higher than those in the non AKI group (P<0.05). The 24hSBPV and 24hDBPV of the AKI group were higher than those of the non AKI group, and the SDNN and PMN50 of the AKI group were lower than those of the non AKI group, the differences were statistically significant (mean P<0.05). The increase of SCR level, 24hSBPV and 24hDBPV at admission, and the prolonged time from onset to emergency were the independent risk factors for AKI in patients with essential hypertension and STEMI (P<0.05); There was no correlation between SDNN, PMN50 and AKI in essential hypertension patients with STEMI (P>0.05). 【Conclusion】 The increase of BPV in patients with essential hypertension and STEMI may lead to AKI. Early monitoring and active intervention are needed for these patients.
刘秀敏. BPV、HRV与原发性高血压合并STEMI患者发生急性肾损伤的相关性分析[J]. 医学临床研究, 2021, 38(6): 870-872.
LIU Xiu-min. Correlation Analysis of BPV, Heart Rate Variability and Acute Kidney Injury in Patients with Essential Hypertension and STEMI. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 870-872.
2021, Vol. 38 
