AQP4、VEGF与成年人脑胶质瘤的瘤周水肿程度的相关性

doi:10.3969/j.issn.1671-7171.2022.06.031

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1234 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨水孔蛋白4(AQP4)、血管内皮细胞生长因子(VEGF)与成年人脑胶质瘤的瘤周水肿程度的相关性。【方法】选取2017年1月至2020年2月本院保存的80例成年人脑胶质瘤组织标本(观察组),同时选取50例正常脑组织作为对照组,采用免疫组化染色检测AQP4、VEGF表达,分析不同级别瘤周水肿患者AQP4、VEGF阳性表达情况。【结果】观察组VEGF、AQP4阳性表达率显著高于对照组,差异有统计学意义(P<0.05)。高级别脑胶质瘤患者VEGF、AQP4阳性表达率明显高于低级别脑胶质瘤患者,差异有统计学意义(P<0.05);不同患者性别、年龄、高血压、糖尿病、高脂血症、肿瘤直径、肿瘤数、肿瘤部位比较,差异无统计学意义(P>0.05)。随着瘤周水肿级别的增加,VEGF、AQP4阳性表达率明显升高(P<0.05)。Spearman秩相关分析显示,脑胶质瘤组织AQP4与VEGF阳性表达呈正相关(r_s=0.451,P<0.05)。【结论】成年人脑胶质瘤组织AQP4、VEGF阳性表达率显著升高,与病理级别、瘤周水肿程度有关。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：脑肿瘤, 神经胶质瘤, 血管内皮生长因子A, 水通道蛋白质4

Abstract：【Objective】 To investigate the relationship between aquaporin 4 (AQP4),vascular endothelial growth factor (VEGF) and peritumoral edema in adult glioma.【Methods】 A total of 80 adult glioma tissue specimens (observation group) preserved in our hospital from January 2017 to February 2020 were selected,and 50 normal brain tissues were selected as the control group. The expression of AQP4 and VEGF was detected by immunohistochemical staining,and the positive expression of AQP4 and VEGF in patients with different levels of peritumoral edema was analyzed. 【Results】The positive expression rates of VEGF and AQP4 in the observation group were significantly higher than those in the control group (P<0.05). The positive expression rates of VEGF and AQP4 in high-grade gliomas were significantly higher than those in low-grade gliomas (P<0.05); There was no significant difference in gender,age,hypertension,diabetes,hyperlipidemia,tumor diameter,tumor number and tumor location (P>0.05). With the increase of peritumoral edema level,the positive expression rates of VEGF and AQP4 increased significantly (P<0.05). Spearman rank correlation analysis showed that the positive expression of AQP4 and VEGF in glioma was positively correlated (r_s=0.451,P<0.05). 【Conclusion】 The positive expression rates of AQP4 and VEGF in adult gliomas are significantly increased,which is related to the pathological grade and the degree of peritumoral edema.

Key words： Brain Neoplasms Glioma Vascular Endothelial Growth Factor A Aquaporin 4

收稿日期: 2021-04-28

中图分类号:

R739.41

通讯作者: *E-mail:120432981@qq.com

引用本文:

罗文颖, 王虎成, 李孝伟, 陈杰, 闫兴尧, 高林涛, 马德. AQP4、VEGF与成年人脑胶质瘤的瘤周水肿程度的相关性[J]. 医学临床研究, 2022, 39(6): 917-920.
LUO Wen-ying, WANG Hu-cheng, LI Xiao-wei,et al. Correlation between AQP4,VEGF and Peritumoral Edema in Adult Gliomas. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 917-920.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.06.031 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I6/917