Abstract：【Objective】To analyze the effect of Xingnaojing combined with edaravone on the levels of vascular endothelial growth factor (VEGF), brain natriuretic peptide (BNP) and copeptin in patients with cerebral hemorrhage. 【Methods】A total of 96 patients with cerebral hemorrhage were selected and divided into the control group and the observation group according to different treatment methods. Both groups were given conventional treatments. Patients in the control group were treated with Xingnaojing alone, while patients in the observation group were treated with Xingnaojing assisted by edaravone. The clinical efficacy of the two groups were analyzed after treatment.【Results】The total effective rate of patients in the observation group was 95.83% (46/48), which was higher than that of the control group 75.00% (36/48, P<0.05). There was no significant difference in the levels of indicators between the two groups before treatment (P>0.05). After treatment, the levels of ET, VEGF, BNP, copeptin, SF, NO, and MDA in the two groups were lower than those before treatment; and the above indicators in the observation group were lower than those in the control group after treatment. The difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference between the two groups in terms of of NIHSS, MoCA (the Montreal cognitive assessment scale), and ADL (activity of daily living scale) scores (P>0.05). After treatment, the NIHSS scores of the two groups were lower than those before treatment, and MoCA and ADL scores were higher than those before treatment. The NIHSS, MoCA and ADL scores of the observation group after treatment were better than those of the control group (P<0.05). 【Conclusion】Xingnaojing combined with edaravone therapy can improve the efficacy of cerebral hemorrhage, reduce the levels of BNF, copeptin, SF, NO, and MDA in patients, and improve the neurological function of patients. It is worthy of clinical application.
贾楠婕, 冯俊杰. 醒脑静联合依达拉奉治疗脑出血对患者VEGF、BNP及和肽素水平的影响[J]. 医学临床研究, 2021, 38(6): 890-892.
JIA Nan-jie, FENG Jun-jie. Effect of Xingnaojing Combined with Edaravone on the Levels of VEGF, BNP and Copeptin in Patients with Cerebral Hemorrhage. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 890-892.
2021, Vol. 38 
