Abstract：【Objective】To detect the expression levels of interferon-γ (IFN-γ), interleukin-10 (IL-10), estradiol (E2) and β-human chorionic gonadotropin (β-hCG) in serum of pregnant syphilis (PS) patients, and to analyze their clinical significance. 【Methods】 A total of 92 patients with pregnancy complicated with PS treated in Xi'an Ninth Hospital from July 2018 to July 2020 were selected as PS group. They were divided into good pregnancy outcome group and bad pregnancy outcome group according to pregnancy outcome; In addition, 85 normal pregnant women who underwent prenatal examination in Xi'an Ninth Hospital in the same period were selected as the control group.The expression level o serum IFN-γ, IL-10, E2 and β-hCG of patients in different groups were compared; The expression level serum IFN-γ, IL-10, E2 and β-hCG was analyzed by receiver operating characteristic curve (ROC)in the value of the diagnosis of adverse pregnancy outcomes in patients with PS; Logistic regression was used to analyze the risk factors of adverse pregnancy outcomes in patients with PS.【Results】 The level of IL-10, E2 and β-hCG of the PS patients was significantly lower than that of the control group (P<0.05), and decreased with the increase of syphilis severity, and the expression level of IFN-γwas significantly higher than that in the control group (P<0.05), and increased with the increase of the severity of syphilis; Compared with the good pregnancy outcome group, the expression level of the serum levels of IL-10, E2 and β-hCG in PS patients of the adverse pregnancy outcome group decreased significantly (P<0.05), and the expression level of IFN-γwas significantly increased (P<0.05); ROC curve showed that the area under the curve (AUC) of serum IFN-γ, IL-10, E2 and β-hCG expression level in the diagnosis of adverse pregnancy outcome in patients with PS were 0.865, 0.821, 0.717 and 0.816 respectively. The AUC of adverse pregnancy outcome in PS patients diagnosed by the combination of the four was 0.936, which was significantly higher than that diagnosed by serum IFN-γ, IL-10, E2 and β-hCG expression alone (P<0.05). 【Conclusion】The expression level in serum IFN-γ, IL-10, E2 and β-hCG in PS patients is closely related to the condition of PS and the adverse pregnancy outcome of PS patients, which has a certain diagnostic value for the occurrence of adverse pregnancy outcome.
2022, Vol. 39 
