Abstract：【Objective】To investigate the relationship the severity of agkistrodon bite with neutrophil-to-lymphocyte ratio (NLR)and platelet-lymphocyte ratio (PLR) levels in patient serum.【Methods】There are 143 cases of patients bitten by agkistrodon in total who were admitted to our Hospital. Of which, 115 patients were selected based on the inclusion and exclusion criteria. According to the Snake Bite Severity Scale (SSS) score, they were divided into 45 cases in the mild group,(0~3 points), 40 cases in the moderate group (4~7 points), and 30 cases in the severe group (8~20 points). During the same time period, 20 healthy volunteers were randomly selected from Health Management Center and divided into the healthy control group. The levels of NLR, PLR, high-sensitivity C-reactive protein(hs-CRP), procalcitonin (PCT), interleukin-1 (IL-1) and interleukin-6 (IL-6) in each group were compared. After that, the relationship of severity of the disease in patients bitten by agkistrodon with levels of NLR and PLR was analyzed.【Results】Serum NLR and PLR were positively correlated with the severity of snake bite (P<0.05). Compared with the control group, the levels of NLR and PLR in the snake poisoning groups were significantly increased (P<0.05). Compared to patients in the mild and moderate groups, the levels of NLR and PLR in the severe group were significantly higher (P<0.05). Compared with the patients in the mild group, the levels of NLR and PLR in the moderate group were Increased (P>0.05). Compared to the control group, the levels of hs-CRP, PCT, IL-1, and IL-6 were significantly higher in the agkistrodon poisoning groups (all P<0.05). Among the poisoning groups, levels of hs-CRP, PCT, IL-1, and IL-6 in the mild group were lower than those in the moderate group and the severe group, however, the difference between the mild group and the moderate group was not statistically significant (All P>0.05) and the difference between the mild group and the severe group was statistically significant (P<0.05).【Conclusion】Both NLR and PLR are positively correlated with the severity of patients bitten by agkistrodon.
曾宪华, 覃双全, 骆立晖. 蝮蛇咬伤患者血清NLR、PLR水平与病情严重程度的相关性[J]. 医学临床研究, 2022, 39(3): 356-358.
ZENG Xian-hua, QIN Shuang-quan, LUO Li-hui. Study on Relationship of Severity of Illness in Patients Bitten by Agkistrodon with Serum NLR and PLR Levels. JOURNAL OF CLINICAL RESEARCH, 2022, 39(3): 356-358.
[1] 韩斐. 北方地区蝮蛇咬伤患者炎性标志物变化规律研究[D].北京:中国人民解放军医学院,2015. [2] CATARINA T,YARA C,VANESSA M,et al.Inflammation induced by bothrops asper venom[J].Toxicon,2009,54(1):67-76. [3] 李学勤,付迎新.NLR和PLR与肺炎支原体肺炎患儿病情严重程度的相关性及对预后的预测价值[J].安徽医学,2020,41(7):813-815. [4] JENNE C N,URRUTIA R,KUBES P. Platelets: bridging hemostasis,inflammation,and immunity[J].Int J Laboratory Hematoloy,2013,35(3):254-261. [5] PRODROMIDOU A,ANDREAKOS P,KAZAKOS C,et al. The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer[J].Inflamm Res,2017,66(6):467-475. [6] 凌玲,吕荣,汤金梅,等. 中性粒细胞/淋巴细胞比值对老年慢性阻塞性肺疾病急性加重期患者并发心力衰竭的预测价值[J].临床内科杂志,2019,36(3):196-198. [7] KUMANO Y,HASEGAWA Y,KAWAHARA T,et al. Pretreatment neutrophil to lymphocyte ratio (NLR) predicts prognosis for castration resistant prostate cancer patients underwent enzalutamide[J].Biomed Res Int,2019,2019:9450838. [8] GOMEZ D,FARID S,MALIK H,et al. Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma[J].World J Surg,2008,32(8):1757-1762. [9] ZHANG J,CHU M. Targeting of IL-6-Relevant long noncoding RNA profiles in inflammatory and tumorous disease[J].Inflammation,2019,42(4):1139-1146. [10] 张平如,张国来. PCT、CRP、NLR联合PLR检测在血流感染早期诊断和预后判断中的价值[J].医学临床研究杂志,2019,36(7):1395-1397.
2022, Vol. 39 
