医学临床研究
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医学临床研究  2022, Vol. 39 Issue (2): 183-186    DOI: 10.3969/j.issn.1671-7171.2022.02.007
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自身免疫性肝炎患者外周血Beclin1、LC3水平及Th1/Th2平衡预测肝功能损伤的价值
郝艳霞, 白红艳**
陕西省榆林市星元医院检验科,陕西 榆林 719000
Value of Peripheral Blood Beclin1, LC3 and Th1/Th2 Balance in Predicting Liver Function Damage in Patients with Autoimmune Hepatitis
HAO Yan-xia, BAI Hong-yan
Department of Laboratory Medicine,The Xingyuan Hospital of Yulin, Yulin 719000
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摘要 【目的】探讨自身免疫性肝炎(AIH)患者外周血自噬相关基因Beclin1、LC3水平及Th1/Th2平衡预测肝功能损伤的价值。【方法】选取本院2017年4月至2020年6月收治的91例AIH患者为研究对象,按是否发生肝功能损伤分为损伤组(27例)和未损伤组(64例)。对比两组临床特征及外周血Beclin1、LC3水平及Th1/Th2平衡,分析影响AIH患者发生肝功能损伤的因素,以受试者工作特征(ROC)曲线下面积(AUC)评估Beclin1、LC3水平及Th1/Th2平衡预测AIH患者发生肝功能损伤的价值。【结果】损伤组C反应蛋白(CRP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清总胆红素(TBIL)、谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、免疫球蛋白IgG、干扰素-γ(INF-γ)、Beclin1、LC3及Th1/Th2均高于未损伤组,白细胞介素-4(IL-4)水平低于未损伤组(P<0.05);Logistic回归分析显示,Beclin1、LC3及Th1/Th2是AIH患者发生肝功能损伤的影响因素(P<0.05);ROC曲线分析结果显示,Beclin1、LC3、Th1/Th2及三者联合AUC分别为0.773、0.844、0.751、0.896,三者联合预测AUC最大。【结论】AIH患者外周血Beclin1、LC3水平过度表达,Th1/Th2平衡趋向于Th1,Beclin1、LC3与Th1/Th2联合检测对AIH肝功能损伤具有较高的预测价值。
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郝艳霞
白红艳
关键词 肝炎,自身免疫性T淋巴细胞,调节性自噬相关蛋白质类肝功能试验肝/损伤    
Abstract:【Objective】To explore the value of Peripheral Blood Beclin1, LC3 and Th1/Th2 balance in predicting liver damage in patients with autoimmune hepatitis (AIH). 【Methods】A total of 91 AIH patients admitted to our hospital from April 2017 to June 2020 were selected as the research objects. According to whether liver damage occurred, they were divided into the liver function injured group (27 cases) and the liver function uninjured group (64 cases). The clinical characteristics of the two groups were compared and the levels of Beclin1, LC3, and Th1/Th2 balance in peripheral blood e that affected the occurrence of liver damage in AIH patients were analyzed. The area under the receiver operating characteristic (ROC) curve (AUC) value was used to evaluate the value of Beclin1,LC3 levels and Th1/Th2 balance in predicting liver function damage in AIH patients. 【Results】The levels of C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum total bilirubin (TBIL), glutamyl transferase (GGT), alkaline phosphatase (ALP), immunoglobulin protein IgG, interferon-γ (INF-γ), Beclin1, LC3 and Th1/Th2 in the liver function injured group were all higher than those in the liver function uninjured group, while the level of interleukin-4 (IL-4) in the injured group was lower than that in the uninjured group (P<0.05). Logistic regression analysis showed that Beclin1, LC3 and Th1/Th2 were the influencing factors of liver damage in AIH patients (P<0.05). ROC curve analysis results showed that Beclin1, LC3, Th1/Th2 alone and the combined AUC of the three were 0.773, 0.844, 0.751 and 0.896, respectively. And the combined AUC of the three was the largest. 【Conclusion】 The levels of Beclin1 and LC3 in the peripheral blood of AIH patients are overexpressed, and the balance of Th1/Th2 tends to Th1. The combined detection of Beclin1, LC3 and Th1/Th2 has a better predictive value for AIH liver damage.
Key wordsHepatitis,Autoimmune    T-Lymphocytes,Regulatory    Autophagy-Related Proteins    Liver Function Tests    Liver/IN
收稿日期: 2021-11-09     
中图分类号:  R575.1  
基金资助:山东省医药卫生科技发展计划项目(No.2018HZ059)
通讯作者: **E-mail:h13399125950@163.com   
引用本文:   
郝艳霞, 白红艳. 自身免疫性肝炎患者外周血Beclin1、LC3水平及Th1/Th2平衡预测肝功能损伤的价值[J]. 医学临床研究, 2022, 39(2): 183-186.
HAO Yan-xia, BAI Hong-yan. Value of Peripheral Blood Beclin1, LC3 and Th1/Th2 Balance in Predicting Liver Function Damage in Patients with Autoimmune Hepatitis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(2): 183-186.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.02.007     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I2/183
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