Abstract：【Objective】To explore the correlation between preoperative blood platelet-to-lymphocyte ratio (PLR) and clinical prognosis of thyroid cancer. 【Methods】A total of 258 cases of thyroid cancer treated in our hospital from January 2018 to January 2021 were enrolled in the study. According to value of PLR, they were divided into group A (PLR ≤ 150, 168 cases) and group B (PLR > 150, 90 cases). The data of preoperative Triiodothyronine (T3),serum total thyroxine (T4) levels, preoperative anti-thyroglobulin antibody (Tg-Ab), anti-thyroid peroxidase antibody (TPO-Ab), Hashimoto's thyroiditis, TNM staging, tumor size, pathological type and lymph node metastasis were collected. All patients were required to have a follow-up visit every 3 months after surgery, for 4 times in total. Ultrasonography was performed for every review, and fine-needle aspiration biopsy pathological examination would be performed, if necessary, to determine the tumor recurrence. Statistical analysis was performed on the obtained data. 【Results】There were no significant differences in Tg-Ab, TPO-Ab, Hashimoto's thyroiditis, TNM staging, and lymph node metastasis between two groups (P>0.05). There were significant differences in serum T3 and T4 levels, tumor size, and pathological types between two groups before surgery (P<0.05). Tumor size, pathological type, and preoperative serum T3 and T4 levels were independent influencing factors of preoperative PLR (P<0.05). There was no significant difference in the tumor recurrence rates between two groups at 6th, 9th and 12th months after surgery (P>0.05). 【Conclusion】Tumor size, pathological type, and preoperative serum T3 and T4 levels are influencing factors of preoperative PLR, but the predictive effect of preoperative PLR on the prognosis of thyroid cancer needs further study.
任博博, 闵琦. 术前血小板淋巴细胞比值与甲状腺癌患者预后的相关性[J]. 医学临床研究, 2021, 38(8): 1183-1186.
REN Bo-bo, MIN Qi. Correlation Between Preoperative Blood Platelet-to-Lymphocyte Ratio and Prognosis of Thyroid Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(8): 1183-1186.
[1] GUARINO V. Thyroid cancer and inflammation[J].Mol Cell Endocrinol,2010, 321(1): 94-102. [2] DOSSUS L, FRANCESCHI S, BIESSY C, et al. Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study[J].Int J Cancer,2018, 142(7): 1332-1342. [3] CHUA T C, CHONG C H, LIAUW W, et al. Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy[J].Ann Surg,2012, 256(2): 342. [4] ELENA D S, MAURA D V, GIULIETTA ANNA P, et al. Overexpression of pro-inflammatory genes and down-regulation of SOCS-1 in human PTC and in hypoxic BCPAP cells[J].Biomed Pharmacother,2013, 67(1): 7-16. [5] SHAO B, WAHRENBROCK M G, YAO L, et al. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome[J].Blood,2011, 118(15): 4015. [6] ACMAZ G, AKSOY H, UNAL D, et al. Are neutrophil/lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding?[J].Asian Pac J Cancer Prev,2014, 15(4): 1689. [7] LEE S, OH S Y, KIM S H, et al. Prognostic significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in advanced gastric cancer patients treated with FOLFOX chemotherapy[J].BMC Cancer,2013, 13(1): 350. [8] FENG JF, HUANG Y, ZHAO Q, et al. Clinical significance of preoperative neutrophil lymphocyte ratio versus platelet lymphocyte ratio in patients with small cell carcinoma of the esophagus[J].Scientific World J,2013, 53(4): 504-505. [9] SERETIS C, SERETIS F, LAGOUDIANAKIS E, et al. Enhancing the accuracy of platelet to lymphocyte ratio after adjustment for large platelet count: a pilot study in breast cancer patients[J].Int J Surg Oncol,2012, 32(2): 65-68.
2021, Vol. 38 
