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医学临床研究  2022, Vol. 39 Issue (1): 85-87    DOI: 10.3969/j.issn.1671-7171.2022.01.023
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低分子右旋糖酐联合大量饮水对羊水过少孕妇血清炎症因子及宫腔环境的影响
史帆, 白瑞*
子洲县人民医院妇产科,陕西 子洲 718499
Effects of Low-Molecular-Weight Dextran Combined with Large Amounts of Drinking Water on Serum Inflammatory Factors and Uterine Environment in Pregnant Women with Oligohydramnios
SHI Fan, BAI Rui
Department of Obstetrics and Gynecology, Zizhou County People's Hospital, Zizhou 718499
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摘要 【目的】探讨低分子右旋糖酐联合大量饮水对羊水过少孕妇血清炎症因子及宫腔环境的影响。【方法】选择2015年1月至2020年12月在本院诊治的羊水过少孕妇112例,按照随机数表法分为低分子右旋糖酐联合大量饮水组、低分子右旋糖酐组、大量饮水组、对照组,每组28例。检测并比较四组孕妇治疗前和治疗7 d后血清炎症因子[血清肿瘤坏死因子-α(Tumor necrosis factor-alpha,TNF-α)、白介素-2(Interleukin-2,IL-2)、IL-6和高敏反应C蛋白(High sensitivity reactive C protein,hs-CRP)]和宫腔环境[羊水指数(amniotic fluid index, AFI)、胎儿脉搏指数(pulse index,PI)、胎儿脐动脉血流收缩期最大血流速率与舒张末期血流速率比值(systolic/diastolic,S/D)]。【结果】四组年龄、入选孕周、胎次、TNF-α、IL-2、hs-CRP、AFI、PI及S/D比较差异无统计学意义(P>0.05)。治疗后,与对照组相比,低分子右旋糖酐联合大量饮水组TNF-α、IL-6、hs-CRP、PI、S/D明显下降,AFI明显升高(P<0.05);分子右旋糖酐组、大量饮水组IL-6、hs-CRP、PI、S/D明显下降,AFI明显升高(P<0.05)。【结论】针对羊水过少患者给予低分子右旋糖酐与大量饮水联合治疗,可改善宫腔环境和血清炎症因子水平。
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史帆
白瑞
关键词 羊水过少孕妇右旋糖酐类/治疗应用饮水炎症介导素类    
Abstract:【Objective】To investigate the effect of low-molecular-weight dextran combined with large amounts of drinking water on serum inflammatory factors and uterine environment in pregnant women with oligohydramnios. 【Methods】A total of 112 pregnant women with oligohydramnios in our hospital from January 2015 to December 2020 were selected. Patients were randomly divided into 4 groups: 28 cases of low molecular dextran combined with large amounts of drinking water group, 28 cases of low molecular dextran group, 28 cases in the large amounts of drinking water group and 28 cases in the control group. The serum inflammatory factors [serum tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and interleukin-6 (Interleukin-6, IL-6), serum high sensitivity reactive C protein (hs-CRP)], uterine cavity environment [amniotic fluid index (AFI), fetal pulse index (pulse index, PI) and the ratio of the maximum systolic blood flow rate of fetal umbilical artery blood flow to the end-diastolic blood flow rate (systolic/diastolic, S/D)] before treatment and 7 days after treatment in the four groups of pregnant women were detected. 【Results】There were no significant differences in age, gestational age, parity, TNF-α, IL-2, hs-CRP, AFI, PI and S/D among the four groups(P>0.05). Compared with the control group, TNF-α, IL-6, hs-CRP, PI, S/D in the low molecular dextran combined with large amounts of drinking water group were significantly decreased, while AFI was significantly increased (P<0.05). The IL-6, Hs-CRP, PI, S/D in low molecular dextran group decreased significantly and AFI increased significantly if they were compared to the control group (P<0.05). Also, compared with the control group, IL-6, hs-CRP, PI, S/D in the large amounts of drinking water group were decreased significantly and AFI was increased significantly (P<0.05). 【Conclusion】Combining low-molecular-weight dextran with large amounts of drinking water in the treatment of oligohydramnios can improve the uterine cavity environment and serum inflammatory factor levels.
Key wordsOligohydramnios    Pregnant Women    Dextrans/TU    Drinking    Inflammation Mediators
收稿日期: 2021-09-07     
中图分类号:  R714.259  
通讯作者: *E-mail:444817161@qq.com   
引用本文:   
史帆, 白瑞. 低分子右旋糖酐联合大量饮水对羊水过少孕妇血清炎症因子及宫腔环境的影响[J]. 医学临床研究, 2022, 39(1): 85-87.
SHI Fan, BAI Rui. Effects of Low-Molecular-Weight Dextran Combined with Large Amounts of Drinking Water on Serum Inflammatory Factors and Uterine Environment in Pregnant Women with Oligohydramnios. JOURNAL OF CLINICAL RESEARCH, 2022, 39(1): 85-87.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.01.023     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I1/85
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