Abstract：【Objective】To investigate the effect of Simiao Decoction on the expression level of inflammatory cytokines and nucleotide binding oligomerization domain-like receptor 3 (NALP3) in patients with acute attack of gout. 【Methods】A total of 102 patients with acute onset of gouty arthritis, who were diagnosed in the inpatient department of our hospital from February 2019 to January 2020, were selected and divided into the observation group and the control group according to the random number table method, with 51 patients in each group. Patients in the control group were treated with colchicine, while patients in the observation group were additionally treated with supplemented Simiao decoction (1 dose per day). Both groups were treated for 14 days continuously. The levels of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 (IL-1) and NALP3 before and after treatment were compared between the two groups. 【Results】The total effective rate in the observation group was 92.16% (47/51), which was significantly higher than that of 74.51% (38/51) in the control group (P<0.05).After treatment, the levels of IL-6, IL-8, IL-1, serum uric acid and NALP3 in the observation group were lower than those in the control group and before treatment (P<0.05).The scores of TCM syndromes and local joint symptoms in the observation group were lower than those in the control group and before treatment (P<0.05).There was no statistically significant difference in the incidence of adverse reactions after treatment between the two groups (P>0.05). 【Conclusion】The treatment of acute gout patients with flavored Simiao decoction can effectively relieve joint symptoms, reduce inflammatory response and uric acid level, and inhibit the activation of serum NALP3 inflammatory body, which is of certain clinical significance.
王苗, 裴益明. 加味四妙汤对痛风急性发作患者血清炎症因子及NALP3表达水平的影响[J]. 医学临床研究, 2022, 39(1): 74-76.
WANG Miao, PEI Yi-ming. Effect of Simiao Decoction on Serum Inflammatory Factors and NALP3 Expression in Patients with Acute Gout Attack. JOURNAL OF CLINICAL RESEARCH, 2022, 39(1): 74-76.
[1] 周厚明,姚真荣,项婷, 等.加味四妙散对急性痛风性关节炎大鼠模型疗效的影响[J].中药材,2018,41(6):1486-1488. [2] 刘璐,张全波,青玉凤, 等.加味四妙散汤剂对大鼠急性痛风性关节炎的疗效及可能作用机制的研究[J].新医学,2017,48(6):375-379. [3] 刘璐,张全波,青玉凤, 等.加味四妙散汤剂对大鼠急性痛风性关节炎的疗效及可能作用机制的研究[J].新医学,2017,48(6):375-379. [4] 高颖,辛雷,赵东宝.《2016中国痛风诊疗指南》解读[J].中国实用内科杂志,2018,38(12):1136-1138. [5] 李国锐.《中医病症诊断疗效标准》出台[J].标准化信息,1995,37(2):5. [6] 中华人民共和国卫生部. 新药(西药)临床前研究指导原则汇编[M].北京:中华人民共和国卫生部药政局, 1993. [7] 郑筱萸. 中药新药临床研究指导原则[M].北京:中国医药科技出版社, 2002:12. [8] 陈海宏,高大伟,张会良, 等.复方四黄液外敷治疗急性痛风性关节炎效果及对炎症反应指标的影响[J].中国老年学杂志,2018,38(3):641-643. [9] 梁晖,张意侗,解纪惠, 等.急性痛风性关节炎患者血清IL-1β IL-6 IL-8与疼痛的相关性[J].河北医学,2019,25(1):22-25. [10] QASEEM A, HARRIS R P, FORCIEA M A.Clinical guidelines committee of the american college of physicians. management of acute and recurrent gout: a clinical practice guideline from the american college of physicians[J].Ann Intern Med,2017,166(1):58-68. [11] 钱凯,张筠雩,李春梅, 等.血尿酸不高的急性痛风患者血清中IL-6、IL-1β和炎症指标的表达水平及临床意义分析[J].标记免疫分析与临床,2018,25(2):183-185. [12] 梁晖,张意侗,解纪惠, 等.急性痛风性关节炎的中药治疗进展[J].中国中医急症,2019,28(3):553-556. [13] NUKI G, DOHERTY M, RICHETTE P. Current management of gout: practical messages from 2016 EULAR guidelines[J].Pol Arch Intern Med,2017,127(4):267-277. [14] 王立祚.加味四妙散汤对急性痛风性关节炎大鼠炎性细胞因子及多靶点调节信号通路影响[J].四川中医,2018,36(4):69-72. [15] 刘敏.加味四妙汤联合塞来昔布治疗湿热蕴结型痛风疗效观察[J].现代中西医结合杂志,2016,25(34):3827-3828.
2022, Vol. 39 
