消化性溃疡患儿Hp感染与hBD-2、PGⅠ/PGⅡ、Th1/Th2水平的相关性及影响因素分析

doi:10.3969/j.issn.1671-7171.2022.01.024

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摘要【目的】探讨消化性溃疡(PU)患儿幽门螺杆菌(Hp)感染与人β2防御素2(hBD-2)、胃蛋白酶(PG)Ⅰ/PG Ⅱ、辅助性T淋巴细胞(Th)1/Th2水平的相关性及影响因素。【方法】选取本院收治的84例PU患儿,根据Hp感染情况分为Hp阳性组(n=31)与Hp阴性组(n=53),比较两组基线资料、炎症评分、hBD-2、PG Ⅰ/PG Ⅱ、Th1/Th2水平,分析hBD-2、PG Ⅰ/PG Ⅱ、Th1/Th2与炎症评分及Hp感染的相关性,探讨PU患儿HP感染的影响因素。【结果】Hp阳性组hBD-2、PG Ⅰ/PG Ⅱ、炎症评分高于Hp阴性组,Th1/Th2低于Hp阴性组(P<0.05)。hBD-2、PG Ⅰ/PG Ⅱ与Hp阳性患儿炎症评分均呈正相关性,Th1/Th2与Hp阳性患儿炎症评分呈负相关性(P<0.05);hBD-2、PG Ⅰ/PG Ⅱ与Hp感染均呈正相关性,Th1/Th2与Hp感染呈负相关性(P<0.05)。照顾者胃肠道疾病史、个人卫生良好、分餐情况、吸吮手指、hBD-2、PG Ⅰ/PG Ⅱ、Th1/Th2均为PU患儿Hp感染影响因素(P<0.05)。【结论】PU患儿Hp感染与hBD-2、PG Ⅰ/PG Ⅱ、Th1/Th2水平失衡密切相关,且与个人卫生、照顾者胃肠道疾病史等有关。

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	蒋芹
	惠雷

关键词 ：消化性溃疡, 幽门螺杆菌, 儿童, β防御素/分析, Th1细胞, Th2细胞, 影响因素分析

Abstract：【Objective】To investigate the relationship between Helicobacter pylori (HP) infection with hBD-2,PG Ⅰ/PG Ⅱ and Th 1/Th2 levels in children with peptic ulcer (PU),and its influencing factors. 【Methods】A total of 84 children with PU treated in our hospital was divided into HP positive group (n=31) and HP negative group (n=53) according to the situation of HP infection. The baseline data, inflammatory score, hBD-2, PG Ⅰ/PG Ⅱ and Th1/Th2 levels of the two groups were compared. The correlation between hBD-2, PG Ⅰ/PG Ⅱ and Th1/Th2 and inflammatory score and HP infection was analyzed to explore the influencing factors of HP infection in children with PU. 【Results】The scores of hBD-2, PG Ⅰ/PG Ⅱ and inflammation in the HP positive group were higher than those in the HP negative group, and Th1/Th2 were lower than those in the HP negative group (P<0.05). HBD-2, PG Ⅰ/PG Ⅱ were positively correlated with the inflammatory score of HP positive children, and Th1/Th2 was negatively correlated with the inflammatory score of HP positive children (P<0.05); HBD-2, PG Ⅰ/PG Ⅱ were positively correlated with HP infection, and Th1/Th2 was negatively correlated with HP infection (P<0.05). The history of gastrointestinal diseases, good personal hygiene, meal sharing, finger sucking, hBD-2, PG Ⅰ/PG Ⅱ and Th1/Th2 were the influencing factors of HP infection in children with PU (P<0.05). 【Conclusion】HP infection in children with PU is closely related to the imbalance of hBD-2, PG Ⅰ/PG Ⅱ and Th1/Th2 levels, as well as personal hygiene and the history of gastrointestinal diseases of caregivers.

Key words： Peptic Ulcer Helicobacter pylori Child beta-Defensins/AN Th1 Cells Th2 Cells Root Cause Analysis

收稿日期: 2021-09-03

中图分类号:

R573.1

通讯作者: *E-mail:38449380@qq.com

引用本文:

蒋芹, 惠雷. 消化性溃疡患儿Hp感染与hBD-2、PGⅠ/PGⅡ、Th1/Th2水平的相关性及影响因素分析[J]. 医学临床研究, 2022, 39(1): 88-90.
JIANG Qin, HUI Lei. Correlation and Influencing Factors between Hp Infection and hBD-2, PG Ⅰ/PG Ⅱ and Th1/Th2 Levels in Children with Peptic Ulcer. JOURNAL OF CLINICAL RESEARCH, 2022, 39(1): 88-90.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.01.024 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I1/88

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