Abstract：【Objective】To investigate the effect of early enteral nutrition support containing probiotics on the intestinal flora and gastrointestinal function in patients with severe acute pancreatitis (SAP). 【Methods】A total of 106 SAP patients in our hospital from June 2018 to December 2020 were selected and divided into the observation group and the control group by random number table, with 53 cases in each group. The control group received routine early enteral nutrition support, and the observation group received early enteral nutrition support containing probiotics. Both were treated for 2 weeks. The gastrointestinal function scores, acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) scores, nutritional parameters [prealbumin (PA), albumin (ALB), transferrin (TRF)], intestinal flora indicators (lactobacillus, escherichia coli, enterococcus, enterobacteria), serum humoral immune function [immunoglobulin M (IgM), immunoglobulin G (IgG), immunoglobulin A (IgA)] were compared between the two groups before treatment and 2 weeks after treatment. The recovery status of patients and the incidence of infection were counted. 【Results】After 2 weeks of treatment, the gastrointestinal function scores and APACHEⅡ scores of the two groups were lower than before treatment, however, the above parameters in the observation group were lower than the control group, the difference was statistically significant (P<0.05). The serum index (PA, ALB and TRF) levels in both groups after treatment were higher than before treatment; And these indexes in the observation group were higher than those in the control group after 2 weeks of treatment, the difference was statistically significant (P<0.05). The numbers of lactobacillus and escherichia coli in the observation group were higher than those in the control group after 2 weeks of treatment, and the numbers of enterococcus and enterobacter were lower than those in the control group. The differences were statistically significant (P<0.05). After 2 weeks of treatment, the serum IgM, IgG and IgA levels in the two groups were higher than those before treatment. And the IgM, IgG and IgA levels in the observation group were higher than those in the control group; the difference was statistically significant (P<0.05). In the observation group, the relief time of abdominal distension, relief time of abdominal pain, gastrointestinal function recovery time, and hospitalization time were shorter than those of the control group, and the infection rate was lower than that of the control group (P<0.05). 【Conclusion】Early enteral nutrition support with probiotics plays an important role in patients with SAP by regulating the intestinal flora, enhancing immunity, and improving nutritional status. At the same time, it can promote the recovery of intestinal barrier function, prevent intestinal infection, and improve the prognosis.
刘真真, 胡辉歌, 申高飞, 朱飞, 李进鹏, 郑君仪, 黄蕊. 早期肠内营养支持联合益生菌治疗对SAP患者肠道菌群及胃肠功能的影响[J]. 医学临床研究, 2021, 38(11): 1663-1666.
LIU Zhen-zhen, HU Hui-ge, SHEN Gao-fei, et al. Effect of Early Enteral Nutrition Support with Probiotics on Intestinal Flora and Gastrointestinal Function of Patients with Severe Acute Pancreatitis. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1663-1666.
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2021, Vol. 38 
