Abstract：【Objective】To investigate the changes of serum sICAM-1, P-selectin and D-dimer(D-D) levels in patients with acute pancreatitis and their relationship with the severity of the disease. 【Methods】Patients with mild pancreatitis (MAP,n=36) and severe pancreatitis (SAP,n=44) plus 25 healthy people (control group) were selected for the study. On day 1 (d1) and day 7 (d7) of hospital admission, venous blood was collected to detect sICAM-1, P-selectin and D-D . The changes and correlations of each index in the three groups were analyzed. 【Results】On the first day of admission, the levels of sICAM-1, P-selectin and D-D in all subjects were SAP group >MAP group>control group (P<0.05). On d7, the levels of sICAM-1 and P-selectin in the MAP group and SAP group were significantly lower than those on d1 (P<0.05), while the D-D level was higher than that of d1 (P<0.05).Furthermore, the levels of P-selectin and sICAM-1 in the MAP group were significantly lower than those in the SAP group (P<0.05), while the level of D-D were the opposite (P<0.05). Pearson or Spearman correlation analysis showed that sICAM was positively correlated with P-selectin and D-D (P<0.01) and P-selectin was positively correlated with D-D (P<0.01) on d1 and d7. 【Conclusion】The changes of sICAM-1, P-selectin and D-D are closely related to the occurrence and development of acute pancreatitis, which can be used as biological indicators for evaluating the condition of patients with acute pancreatitis.
张玲, 黄莺, 杨婷婷. sICAM-1、P-选择素及D-二聚体在急性胰腺炎患者中的变化及相关性[J]. 医学临床研究, 2019, 36(8): 1478-1479.
ZHANG Ling, HUANG Yin, YANG Ting-ting. Changes of sICAM-1, P- selectin and D-dimer Associating with the Severity of Acute Pancreatitis. JOURNAL OF CLINICAL RESEARCH, 2019, 36(8): 1478-1479.
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2019, Vol. 36 
