医学临床研究
  2025年4月5日 星期六           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2021, Vol. 38 Issue (11): 1663-1666    DOI: 10.3969/j.issn.1671-7171.2021.11.017
  论著 本期目录 | 过刊浏览 | 高级检索 |
早期肠内营养支持联合益生菌治疗对SAP患者肠道菌群及胃肠功能的影响
刘真真1, 胡辉歌2, 申高飞1, 朱飞1, 李进鹏1, 郑君仪1, 黄蕊1*
1.西安市人民医院西安市第四医院,陕西 西安 710004;
2.西安国际医学中心医院消化内科,陕西 西安 710000
Effect of Early Enteral Nutrition Support with Probiotics on Intestinal Flora and Gastrointestinal Function of Patients with Severe Acute Pancreatitis
LIU Zhen-zhen, HU Hui-ge, SHEN Gao-fei, et al
Xi'an People's Hospital(Xi'an Fourth Hospital,Xi'an 710004, Shaanxi
全文: PDF (1192 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】探讨早期肠内营养支持联合益生菌治疗对重症急性胰腺炎(SAP)患者肠道菌群及胃肠功能的影响。【方法】选取2018年6月至2020年12月本院收治的106例SAP患者的临床资料,按照随机数表法将其分为观察组、对照组,各53例。对照组给予常规早期肠内营养支持,观察组在对照组的基础上给予益生菌,均治疗2周。比较两组治疗前、治疗2周后胃肠功能评分、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、营养参数[前白蛋白(PA)、白蛋白(ALB)、转铁蛋白(TRF)]、肠道菌群指标(乳酸杆菌、大肠杆菌、肠球菌、肠杆菌)、血清体液免疫功能[免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)],并统计患者恢复情况与感染发生率。【结果】治疗2周后,两组患者胃肠功能评分、APACHEⅡ评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清PA、ALB、TRF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组乳酸杆菌、双歧杆菌数量均高于治疗前,肠球菌、肠杆菌数量低于治疗前,且观察组与对照组比较差异有统计学意义(P<0.05);两组血清IgM、IgG、IgA水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组腹胀缓解时间、腹痛缓解时间、胃肠功能恢复时间、住院时间低于对照组,感染率低于对照组,差异有统计学意义(P<0.05)。【结论】早期肠内营养支持联合益生菌可调节SAP患者肠道菌群,增强免疫功能,改善营养状态,同时可促进肠道屏障功能恢复,改善预后。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
关键词 胰腺炎,急性坏死性/药物疗法肠道营养/药理学有益菌种/药理学肠/微生物学胃肠活动    
Abstract:【Objective】To investigate the effect of early enteral nutrition support containing probiotics on the intestinal flora and gastrointestinal function in patients with severe acute pancreatitis (SAP). 【Methods】A total of 106 SAP patients in our hospital from June 2018 to December 2020 were selected and divided into the observation group and the control group by random number table, with 53 cases in each group. The control group received routine early enteral nutrition support, and the observation group received early enteral nutrition support containing probiotics. Both were treated for 2 weeks. The gastrointestinal function scores, acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) scores, nutritional parameters [prealbumin (PA), albumin (ALB), transferrin (TRF)], intestinal flora indicators (lactobacillus, escherichia coli, enterococcus, enterobacteria), serum humoral immune function [immunoglobulin M (IgM), immunoglobulin G (IgG), immunoglobulin A (IgA)] were compared between the two groups before treatment and 2 weeks after treatment. The recovery status of patients and the incidence of infection were counted. 【Results】After 2 weeks of treatment, the gastrointestinal function scores and APACHEⅡ scores of the two groups were lower than before treatment, however, the above parameters in the observation group were lower than the control group, the difference was statistically significant (P<0.05). The serum index (PA, ALB and TRF) levels in both groups after treatment were higher than before treatment; And these indexes in the observation group were higher than those in the control group after 2 weeks of treatment, the difference was statistically significant (P<0.05). The numbers of lactobacillus and escherichia coli in the observation group were higher than those in the control group after 2 weeks of treatment, and the numbers of enterococcus and enterobacter were lower than those in the control group. The differences were statistically significant (P<0.05). After 2 weeks of treatment, the serum IgM, IgG and IgA levels in the two groups were higher than those before treatment. And the IgM, IgG and IgA levels in the observation group were higher than those in the control group; the difference was statistically significant (P<0.05). In the observation group, the relief time of abdominal distension, relief time of abdominal pain, gastrointestinal function recovery time, and hospitalization time were shorter than those of the control group, and the infection rate was lower than that of the control group (P<0.05). 【Conclusion】Early enteral nutrition support with probiotics plays an important role in patients with SAP by regulating the intestinal flora, enhancing immunity, and improving nutritional status. At the same time, it can promote the recovery of intestinal barrier function, prevent intestinal infection, and improve the prognosis.
Key wordsPancreatitis, Acute Necrotizing/DT    Enteral Nutrition/PD    Probiotics/PD    Intestines/MI    Gastrointestinal Motility
收稿日期: 2021-03-30     
中图分类号:  R576.1  
通讯作者: *E-mail:sangyahr@163.com   
引用本文:   
刘真真, 胡辉歌, 申高飞, 朱飞, 李进鹏, 郑君仪, 黄蕊. 早期肠内营养支持联合益生菌治疗对SAP患者肠道菌群及胃肠功能的影响[J]. 医学临床研究, 2021, 38(11): 1663-1666.
LIU Zhen-zhen, HU Hui-ge, SHEN Gao-fei, et al. Effect of Early Enteral Nutrition Support with Probiotics on Intestinal Flora and Gastrointestinal Function of Patients with Severe Acute Pancreatitis. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1663-1666.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.11.017     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I11/1663
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn