Abstract：【Objective】 To analyze the drug resistance and related drug resistance genotypes of Pseudomonas aeruginosa (PA). 【Methods 】 A total of 270 PA strains isolated from the laboratory department of Shanghai Electric Power Hospital were collected, the sensitivity of PA to 15 commonly used antibiotics was analyzed, and the expression of mexxy and mexab resistance genes was detected by RT-PCR. 【Results】The elderly aged 60 and above were most infected with Pseudomonas aeruginosa, 221 people, accounting for 81.86%, followed by 37 cases aged 30 ~ 60, accounting for 13.70%, and 12 cases aged 30 and below, accounting for 4.44%. The main source of PA was sputum, the detection rate was 47.04%, followed by urine (26.67%), wound (11.85%) and pharyngeal swab (11.85%). PA is mainly distributed in respiratory medicine, urology and neurology, of which 81 are most widely distributed in respiratory medicine, accounting for 30.00%. The resistance rates of PA to antibiotics from high to low were ticarcillin/clavulanic acid (24.07%), ciprofloxacin (23.70%), levofloxacin (22.96%), piperacillin (22.59%), ceftazidime (21.86%), imipenem (19.26%), aztreonam (19.26%), meropenem (18.52%), gentamicin (15.93%), tobramycin (15.56%) and cefepime (11.11%) , Cefoperazone/sulbactam (11.11%), piperacillin/tazobactam (10.37%), amikacin (8.15%) and polymyxin B (0.00%). Mexxy was expressed in 30% of PA strains, mexab was expressed in 42% of strains, and 16% of them were co expressed.【Conclusion】The elderly aged 60 and above in respiratory department ward are most vulnerable to PA infection. Overexpression of mexxy and mexab in active efflux system is one of the mechanisms of PA multidrug resistance.
马爱矿, 高华丽, 王敏, 王晓明, 李梦, 顾铮, 王晓蓉. 铜绿假单胞菌耐药性及相关耐药基因分型情况分析[J]. 医学临床研究, 2021, 38(10): 1526-1529.
MA Ai-kuang, GAO Hua-li, WANG Min, et al. Analysis of Drug Resistance and Related Drug Resistance Genotyping of Pseudomonas Aeruginosa. JOURNAL OF CLINICAL RESEARCH, 2021, 38(10): 1526-1529.
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2021, Vol. 38 
