Abstract：【Objective】 To investigate the serum levels of lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) in patients with primary sclerosing cholangitis (PSC) and their relationship with prognosis. 【Methods】 87 patients with PSC from January 2008 to January 2014 were selected as the study subjects. The serum levels of LBP and sCD14 were measured by ELISA, and the relationship between them and the prognosis of patients with PSC was analyzed. 【Results】 The incidence of poor prognosis was 40.23% (35/87) in 87 patients with PSC, including 11 cases of liver failure (12.64%), 8 cases of hepatobiliary carcinoma (9.20%), 12 cases of secondary biliary cirrhosis (13.79%) and 4 cases of death (4.60%). The serum levels of LBP and sCD14 in patients with poor prognosis were higher than those in patients with good prognosis (P<0.05). Logistic multivariate regression analysis showed that ALB, TBIL, IL-8, LBP and sCD14 were closely related to the prognosis of PSC patients (P<0.05). The A UC of model C in evaluating the prognosis of PSC patients was higher than that of model A and model B (P<0.05). 【Conclusion】 Serum LBP and sCD14 are correlated with the prognosis of patients with PSC. Detection of serum LBP and sCD14 is helpful to evaluate the prognosis of patients with PSC.
李知翰, 张西亮. 原发性硬化性胆管炎患者血清LBP和sCD14水平及与预后的关系[J]. 医学临床研究, 2021, 38(4): 549-552.
LI Zhi-han, ZHANG Xi-liang. Serum Levels Of Lbp and Scd14 in Patients with Primary Sclerosing Cholangitis and Their Relationship with Prognosis. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 549-552.
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2021, Vol. 38 
