Clinical Effect of Terazosin Combined with Tamsulosin in the Treatment of Benign Prostatic Hyperplasia and its Impact of the Level on Serum PSA and TNF- α
XU Juan, LI Xiao-xue
Ankang Center for Disease Control and Prevention, Ankang 725000, Shaanxi
Abstract：【Objective】To investigate the clinical effect of terazosin combined with tamsulosin on patients with benign prostatic hyperplasia and its effect on the level of the impact of serum PSA and TNF-α. 【Methods】 The clinical data of 102 patients with benign prostatic hyperplasia in our hospital from December 2017 to April 2019 were retrospectively analyzed. According to different treatment schemes, they were divided into observation group (n=50) and control group (n=52). The control group was treated with terazosin, and the observation group was treated with tamsulosin on the basis of the control group. The clinical effect, serum prostate specific antigen (PSA) and tumor necrosis factor-α (TNF)-α were compared between the two groups. The maximum urine flow, residual urine volume and International Prostate Symptom Score (IPSS) were recorded. 【Results】The total effective rate of the observation group was 92.0% (46/50), significantly higher than 86.5% (45/52) of the control group, the difference was statistically significant(χ2=2.8319,P=0.004<0.05).After treatment, the level of serum TNF- αand PSA of the observation group was significantly higher than that of the control group, there was significant difference between the two groups (P<0.05). After treatment, the maximum urine flow and IPSS score of the observation group were significantly higher than those of the control group, and the residual urine volume of the observation group was significantly lower than that of the control group (P<0.05).【Conclusion】 Terazosin combined with tamsulosin can effectively improve the maximum urine flow and residual urine volume of patients with benign prostatic hyperplasia, reduce the level of PSA, and improve the anti-inflammatory immune effect, which is worthy of clinical application.
徐娟, 李小雪. 特拉唑嗪联合坦索罗辛治疗前列腺增生患者的临床效果及对血清PSA、TNF-α水平的影响[J]. 医学临床研究, 2021, 38(6): 873-875.
XU Juan, LI Xiao-xue. Clinical Effect of Terazosin Combined with Tamsulosin in the Treatment of Benign Prostatic Hyperplasia and its Impact of the Level on Serum PSA and TNF- α. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 873-875.
2021, Vol. 38 
