Abstract：【Objective】To explore the predictive effect of serum vascular endothelial cadherin (VE-Cad) on the assessment of the severity of septic shock and the survival status. 【Methods】A total of 78 patients with septic shock who were treated in our hospital were selected as subjects. Serum VE-Cad levels were measured in all patients.According to the value of VE-Cad, patients were divided into three groups: VE-cad level <1ng/ml group(A group, n=29),VE-cad level was 1～ 5 ng/ml group(B group, n=27),VE-cad level >5 ng/ml group(C group, n=22).Vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) levels, APACHE Ⅱ(acute physiology and chronic health) score and SOFA (sequential organ failure estimates) score, and survival rate were compared among patients within three groups. 【Results】The levels of VEGF, TNF-α and IL-6 in the three groups of patients from low to high order was group A < group B < group C, and the differences between the groups were significant (P<0.05). The order from low to high scores of APACHEⅡ and SOFA in the three groups scores was group A < group B < group C; and the differences between each group were significant (P<0.05). The survival rate of patients in group A is 72.41% (21/29), which is higher than 55.56% (15/27) in group B and 40.91% (9/22) in group C; and the differences between the three groups were significant (P<0.05). 【Conclusion】Serum VE-Cad is closely related to the severity of the disease in patients with septic shock. The higher the serum VE-Cad, the more severe the inflammatory response and illness, and the lower the survival rate.
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2020, Vol. 37 
