Abstract：【Objective】To investigate the clinical characteristics of primary central nervous system (CNS) germline cell tumor (GCTs) and to investigate the diagnostic significance of immunohistochemical indexes (CD117, PLAP, CD30, CK and AFP). 【Methods】A retrospective analysis of 14 cases of central nervous system GCTs in Foshan First People's Hospital from May 2018 to June 2020 were studied. Clinical characteristics and immunohistochemical results were analyzed. 【Results】 There were 6 cases of GCTs in sellar region, of which 3 cases were germ cell tumors, 1 case was yolk sac tumor and 1 case was mature teratoma. Two cases occurred in the pineal gland, of which one was a germ cell tumor and the other was a mixed germ cell tumor with embryonic carcinoma component. One patient was a germ cell tumor in the third ventricle. Three cases occurred in the sacrococcyx, of which 2 cases were yolk sac tumor with mature teratoma and 1 case was yolk sac tumor. The last 2 cases occurred in the frontal lobe. The tumors were mainly intracranial hypertension and local compression symptoms. PLAP and CD117 were expressed in almost all germ cell tumors, AFP was expressed in yolk sac tumors, and CD30 and CK were characteristic in embryonic carcinoma. 【Conclusion】 Primary germ cell tumor of central nervous system is a rare type of tumors, which are prone to occur in sella region. According to the biological characteristics, the selection of landmark immunohistochemical indexes for accurate pathological diagnosis has important guiding significance for clinical treatment.
李巧稚, 石海燕, 李旭峰. 14例原发性中枢神经系统生殖细胞肿瘤临床病理特征分析[J]. 医学临床研究, 2020, 37(11): 1697-1700.
LI Qiao-zhi, SHI Hai-yan, LI Xu-feng. Clinicopathologic Features of 14 Primary Germ Cell Tumors from Central Nervous System. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1697-1700.
[1] Thakkar JP, Chew L, Villano JL. Primary CNS germ cell tumors: current epidemiology and update on treatment[J].Med Oncol,2013, 30(2): 496-515. [2] Lee D, Suh YL. Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute[J].Virchows Arch,2010, 457(3): 347-357. [3] Liang SY, Yang TF, Chen YW, et al.Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment[J].Neuro Oncol,2013, 15(11): 1543-1551. [4] Kaur H, Singh D, Peereboom DM. Primary central nervous system germ cell tumors[J].Curr Treat Options Oncol,2003, 4(6): 491-498. [5] Hoei-Hansen CE, Sehested A, Juhler M, et al. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers[J].J Pathol,2006, 209(1): 25-33. [6] Sano K. Pathogenesis of intracranial germ cell tumors reconsidered[J].J Neurosurg,1999,90(2): 258-264. [7] Brandes AA, Pasetto LM, Monfardini S. The treatment of cranial germ cell tumours[J].Cancer Treat Rev,2000,26(4): 233-242. [8] Ogawa K, Toita T, Nakamura K, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors: a multiinstitutional retrospective analysis of 41 patients[J].Cancer,2003, 98(2): 369-376. [9] Gao YP, Jiang JY, Liu Q. Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience[J].Clin Exp Pathol,2014,7(10):6965-6972. [10] Shibamoto Y, Takahashi M, Sasai K. Prognosis of intracranial germinoma with syncytiophoblastic giant cells treated by radiation therapy[J].Int J Radiat Oncol Biol Phys,1997, 37(3): 505- 510. [11] Sugiyama K, Arita K, Tominaga A, et al. Morphologic features of human chorionic gonadotropinor alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning[J].Brain Tumor Pathol,2001, 18(2): 115-122. [12] Wildi-Runge S, Crevier L, Carret AS, et al. Pitutary choriocarcinoma in an adolescent male: tumor-derived CG and GH delay diagnosis[J].Growth Horm IGF Res,2011, 21(3): 181-184.
2020, Vol. 37 
