Abstract：【Objective】 To investigate the expression of sex-determining region Y-box protein 18 (SOX18) in prostate cancer and its relationship with long-term prognosis. 【Methods】 A total of 140 patients with prostate cancer treated in our hospital from January 2012 to March 2017 were selected as the prostate cancer group, and 112 patients with benign prostatic hyperplasia were selected as the control group. The expression of SOX18 was detected by immunohistochemical staining, and the prognosis of patients was followed up. 【Results】 The positive expression rate of SOX18 in prostate cancer group was 70.00% (98/140), which was significantly higher than that in control group 40.18% (45/112). The difference was statistically significant (P<0.05). The positive expression rates of SOX18 in patients with TNM stage Ⅲ-Ⅳ, pathological grade G3-G4, PSA level > 20 ng/mL and Gleason score≥ 8 were 88.24%, 83.05%, 88.89% and 80.49%, respectively, which were significantly higher than those in patients with stage Ⅰ-Ⅱ, G1-G2, prostate specific antigen (PSA)≤20 ng/mL and Gleason score ≤7 (P<0.05). The median overall survival time of SOX18 positive patients was 50 months, which was significantly shorter than that of SOX18 negative patients (70 months); the difference was statistically significant (P<0.05). COX regression analysis showed that TNM stage, Gleason score and SOX18 expression were the prognostic factors of prostate cancer patients (HR=2.748,2.392 and 1.426, P<0.05). 【Conclusion】 The expression of SOX18 in prostate cancer is significantly up-regulated, which are related to clinical stage, pathological grade, PSA and Gleason, and also affect the prognosis of patients.
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2020, Vol. 37 
