Abstract：【Objective】 To explore the diagnostic value of individualized and combined detection of serum prostate cancer-associated lncRNA transcript 1(PCTA-1), carcinoembryonic antigen(CEA)and saccharide antigen199 (CA199) levels in patients with colorectal cancer (CRC). 【Methods】 A total of 182 newly diagnosed CRC patients (CRC group), 80 patients with colorectal polyps (benign group) and 80 healthy people (control group) were selected as the research objects.Serum PCTA-1, CEA and CA199 levels were measured by fasting venous blood collection, and the changes of serum PCTA-1, CEA and CA199 levels were compared between groups and between clinicopathological features.ROC curve was drawn to analyze the diagnostic value of serum PCTA-1, CEA, CA199 levels and combined diagnosis for CRC. 【Results】 The serum levels of PCAT-1, CEA and CA199 in the CRC group were significantly higher than those in the benign group and the control group, and those in the benign group were significantly higher than those in the control group, with statistical significance (P<0.05). With the decrease of differentiation of CRC, the increase of clinical TNM pathological stages and lymph node metastasis, the serum levels of PCAT-1, CEA and CA199 showed an upward trend. There was significant difference between the groups with serum CEA and CA199 levels (P<0.05).The diagnostic AUC of serum PCAT-1, CEA, CA199, PCAT-1+CEA, PCAT-1+CA199 and their combination were 0.791, 0.631, 0.683, 0.822, 0.848 and 0.836, respectively. The sensitivity was 75.25%, 60.21%, 59.25%, 68.70%, 73.35% and 70.05%, and the specificity was 65.32%, 77.22%, 80.25%, 79.36%, 83.75% and 75.73%, respectively.The diagnostic sensitivity of PCAT-1 to CRC was higher than that of CEA and CA199, but the diagnostic specificity was lower than that of CEA and CA199 (P<0.05); the diagnostic value of PCAT-1+CEA, PCAT-1+CA199, PCAT-1+CEA+CA199 was higher than that of PCAT-1, CEA and CA199 alone, and the diagnostic specificity of PCAT-1 combined with CA199 could significantly improve the diagnostic specificity of CRC (P<0.05). 【Conclusion】 The elevation of serum PCAT-1, CEA and CA199 levels contributes to the early diagnosis of CRC, and joint detection has more diagnostic advantages, especially PACT-1 combined with CA199 detection, which can reduce the missed diagnosis rate of CRC and has clinical significance.
陆王锋, 刘磊, 张永宏. 血清PCAT-1联合CEA、CA199检测在结直肠癌患者中的诊断价值[J]. 医学临床研究, 2020, 37(10): 1500-1503.
LU Wang-feng, LIU Lei, ZHANG Yong-hong. Diagnostic Value of Serum PCAT-1 Combined with CEA and CA199 in Patients with Colorectal Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1500-1503.
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2020, Vol. 37 
