失代偿期乙型肝炎肝硬化患者血清PA、MMP-2、CYFRA21-1水平及意义

doi:10.3969/j.issn.1671-7171.2020.11.028

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摘要【目的】探讨失代偿期乙型肝炎(乙肝)肝硬化患者血清前白蛋白(PA)、基质金属蛋白酶-2(MMP-2)、细胞角蛋白19片段(CYFRA21-1)水平及意义。【方法】慢性乙肝患者68例(慢性组)、乙肝肝硬化代偿期患者50例(代偿组)、乙型肝炎肝硬化失代偿期患者42例(失代偿组),同时选取健康志愿者60例作为对照组,检测比较其血清PA、MMP-2、CYFRA21-1水平。【结果】血清PA水平由低至高依次为失代偿组、代偿组、慢性组和对照组,且各组之间相比较差异均有显著性(P<0.05),而MMP-2和CYFRA21-1由高至低依次为失代偿组、代偿组、慢性组和对照组,且各组之间相比较差异均有显著性(P<0.05)。失代偿组死亡患者血清PA为(37.22±9.94)mg/L,明显低于存活患者(P<0.05),而MMP-2和CYFRA21-1为(1.50±0.27)ng/L和(1.56±0.24)ng/mL,明显高于存活患者(P<0.05);血清PA、MMP-2、CYFRA21-1水平预测乙型肝炎肝硬化失代偿期患者死亡的ROC曲线下面积分别为0.911、0.736和0.686(均P<0.05)。【结论】失代偿期乙肝肝硬化患者血清PA明显降低,而MMP-2和CYFRA21-1明显升高,三者在预测预后方面有一定应用价值。

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	夏笑笑
	史冬涛

关键词 ：肝炎, 乙型/并发症, 肝硬化/病因学, 基质金属蛋白酶2/血液, 前白蛋白/血液, 角蛋白类/血液

Abstract：【Objective】To investigate the levels and significance of serum prealbumin (PA), matrix metalloproteinase-2 (MMP-2) and cytokeratin 19 fragment (CYFRA21-1) in patients with decompensated hepatitis B(HB) cirrhosis. 【Methods】Sixty-eight patients with chronic HB (chronic group), 50 patients with compensatory HB cirrhosis (compensatory group) and 42 patients with decompensated HB cirrhosis (decompensated group) were selected,and 60 healthy volunteers were selected as control group;serum PA, MMP-2 and CYFRA21-1 level were detected. 【Results】The levels of serum PA from low to high were the decompensated group, the bcompensatory group, the chronic group and the control group, and the differences were significant (P<0.05). MMP-2 and CYFRA21-1 from high to low were the decompensated group, the compensatory group, the chronic group and the control group, and there were significant differences among each group (P<0.05). In the decompensated group, serum PA was (37.22±9.94) mg/L, which was significantly lower than that of survival patients (P<0.05), while MMP-2 and CYFRA21-1 were (1.50±0.27) ng/L and (1.56±0.24) ng/mL, which were significantly higher than those of survival patients (P<0.05). The area under ROC curve for predicting death of patients with decompensated hepatitis B cirrhosis by serum PA, MMP-2 and CYFRA21-1 was 0.911, 0.736 and 0.686, respectively( All P<0.05). 【Conclusion】Serum PA is significantly decreased in patients with decompensated hepatitis B cirrhosis, while MMP-2 and CYFRA21-1 are significantly increased in patients with decompensated hepatitis B cirrhosis.The three methods have certain application value in predicting prognosis.

Key words： Hepatitis B/CO Liver Cirrhosis/ET Matrix Metalloproteinase 2/BL Prealbumin/BL Keratins/BL

收稿日期: 2019-08-12

PACS:

R657.31

引用本文:

夏笑笑, 史冬涛. 失代偿期乙型肝炎肝硬化患者血清PA、MMP-2、CYFRA21-1水平及意义[J]. 医学临床研究, 2020, 37(11): 1691-1693.
XIA Xiao-xiao, SHI Dong-tao. Levels and Significance of Serum PA, MMP-2, CYFRA21-1 in Patients with Decompensated Hepatitis B Cirrhosis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1691-1693.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.11.028 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I11/1691

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