Abstract：【Objective】To investigate the serum cholinesterase (CHE) in patients with different degrees of chronic hepatitis B (CHB). 【Methods】The serum CHE, hyaluronic acid (HA), total bile acid (TBA) and coagulation indexes in 60 patients with CHB and 50 healthy persons (control group) were detected. 【Results】Levels of serum CHE and fibrinogen (FIB) in patients with mild, moderate and severe CHB were significantly lower than those in the control group, while levels of HA, TBA, thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (APTT) were significantly higher or longer than those in the control group, and the difference was significanta (P＜0.05). Serum CHE and FIB levels decreased with exacerbations of chronic hepatitis B, and HA, TBA increased, and TT, PT, and APTT were prolonged.Serum CHE and FIB levels decreased with exacerbations of chronic hepatitis B, and HA, TBA increased, and TT, PT, and APTT were prolonged.Pearson correlation analysis showed that serum CHE was negatively correlated with HA, TBA, TT, PT, APTT (P＜0.05), and positively correlated with FIB (P＜0.05).【Conclusion】Serum CHE can effectively reflect the severity of CHB, and its level is related to HA, TBA and the four indexes of coagulation.
秦雪梅,赵琪林. 慢性乙型肝炎患者病情严重程度与血清胆碱酯酶的相关性研究[J]. 医学临床研究, 2017, 34(8): 1478-1480.
QIN Xue-mei, ZHAO Qi-lin. Study on the Correlation between the Severity of Chronic Hepatitis B and Serum Cholinesterase. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1478-1480.
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2017, Vol. 34 
