Abstract：【Objective】 To investigate the correlation between Helicobacter pylori (Hp) infection and liver metastases of gastric cancer. 【Methods】A total of 120 patients with gastric cancer were divided according to the presence of metastases into the liver metastasis group (n=52) and the non-liver metastasis group (n=68). The risk factors of clinical data from the two groups were analyzed by univariate analysis. Factors related to liver metastases of gastric cancer were analyzed by Logistic regression analysis. Based on the results of 14C urea breath test, the patients with liver metastases of gastric cancer were further divided into Hp positive sub-group and Hp negative sub-group, and the survival curves were compared between the two sub-groups. 【Results】There were significant differences between the liver metastasis and non-liver metastasis groups in terms of tumor stage, lymph node metastasis, depth of primary tumor invasion, vascular invasion, tumor size, Borrmann type and Hp infection (P＜0.05). Logistic multivariate regression analysis showed that tumor stage, lymph node metastasis, depth of primary tumor invasion and Hp infection were independent risk factors for liver metastases of gastric cancer. The mean survival time of Hp negative group was significantly longer than that of Hp positive group (P＜0.05). 【Conclusion】Lymph node metastasis, vascular invasion and Hp infection are the independent risk factors of liver metastases of gastric cancer, and Hp infection can affect the progression-free survival time of patients with liver metastases of gastric cancer.
2017, Vol. 34 
