Abstract:【Objective】To investigate the efficacy and safety of retrograde ureteroscopic lithotripsy (RIRS) in the treatment of renal calculi with diameter less than or equal to 2 cm.【Methods】From January 2015 to January 2019, 245 cases of renal calculi with diameter less than or equal to 2 cm were analyzed retrospectively. According to the different operation methods, they were divided into the RIRS group (n=122) and the PCNL group (n=123). The operation related indexes, stone finding rate, one week clearance rate, final stone clearance rate and complication rate were compared between the two groups. 【Results】The average operation time and postoperative hospitalization time of the RIRS group were shorter than that of the PCNL group, and the average lithotripsy time was longer than that of the PCNL group (P<0.05). One week stone clearance rate of the RRIS group was lower than that of the PCNL group (P<0.05). There was no significant difference between the two groups in stone finding rate and final stone clearance rate (P>0.05). The incidence of postoperative complications in RIRS group was 5.74% (7 / 122) lower than that in PCNL group (23.58%) (29 / 123), the difference was statistically significant (χ2=5.942,P=0.021<0.05).【Conclusion】RIRS can achieve the same effect as PCNL in the treatment of renal calculi ≤ 2 cm, but its safety is significantly higher than PCNL. It can be used as a surgical method for the treatment of renal calculi ≤ 2 cm in diameter.