Abstract：【Objective】To investigate the effect of propranolol on the expression of VEGF and its receptorsVGFR1/VEGFR2 in serum of children with hemangioma. 【Methods】From December 2014 to December 2017, 48 children with hemangioma in our hospital were selected. All the children were given propranolol orally (0.5 mg/kg for less than 3 months, 1 mg/kg for 3~6 months, 2 mg/kg for more than 6 months, twice a day, a total of 3 months). The levels of VEGF and its receptors VGFR1/VEGFR2 , were recorded before and 3 months after treatment. The tumor volume of the observation group before and 3 months after treatment was measured by ultrasound and the curative effect was evaluated. 【Results】 After one course of treatment, the levels of VEGF and its receptor VGFR1/VEGFR2 protein and mRNA expression in serum were significantly lower than those before treatment (P<0.05). The volume of hemangioma after treatment was (0.29 ± 0.09) cm3, which was significantly lower than that before treatment (0.78 ± 0.15) cm3, the difference was statistically significant (P<0.05). After treatment, Achauer method was used to evaluate the therapeutic effect, including 20 excellent cases, 15 good cases, 7 fair cases and 6 poor cases. The excellent and good rate was 72.9%.【Conclusion】The clinical effect of propranolol is better in children with hemangioma. The mechanism may be related to the down-regulation of serum VEGF and its receptor VGFR1/VEGFR2 expression levels.
李蕾, 梁巍, 陈琛, 张红鹏. 普萘洛尔对血管瘤患儿血清VEGF及其受体VGFR1、VGFR2表达水平的影响[J]. 医学临床研究, 2019, 36(10): 1898-1900.
LI Lei, LIANG Wei, CHEN Chen,et al. Effect of Propranolol on the Expression of VEGF and its Receptors VGFR1/VEGFR2 in Serum of Children with Hemangioma. JOURNAL OF CLINICAL RESEARCH, 2019, 36(10): 1898-1900.
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