Effect of Ginsenoside Rg3 Combined with Neoadjuvant Chemoradiotherapy on the Expression of VEGF and MTA1 Protein in Gastric Cancer Tissues and Prognosis
LI Xiang-wei, ZHANG Zheng-yuan, ZHOU Guang-rong
The First Affiliated Huaian Hospital of NanJing Medical University,Jiangsu Huai'an 223001
Abstract：【Objective】To study the effect of ginsenoside Rg3 combined with neoadjuvant chemoradiotherapy on the expression of VEGF and MTA1 protein in gastric cancer tissues, immune function and prognosis. 【Methods】A total of 84 patients with gastric cancer were randomized into the control group and the treatment group according to different methods of treatment. The control group was given neoadjuvant concurrent radiotherapy and chemotherapy before operation, while the experimental group was treated with ginsenoside Rg3 in addition to concurrent radiotherapy and chemotherapy. The changes of expression of VEGF and MTA1 protein, immune function and prognosis were compared between the two groups before and after treatment. 【Results】The RO resection rate and the total effective rate of the treatment group were higher than those of the control group (P<0.05). Compared to pretreatment, the positive rates of VEGF and MTA1 post-treatment in both groups were significantly reduced (P<0.05), and the decrease in the experimental group was significantly greater than that in the control group (P<0.05). After treatment, the percentage of CD3+ and CD4+, CD4+/CD8+ value and conversion rate of T cells in the experimental group increased significantly compared to the control group (P<0.05), while the percentage of CD8+ decreased significantly (P < 0.05). There was no significant difference in the incidence of bone marrow suppression between the two groups (P>0.05). The recurrence rate in the experimental group was low than the control group (P<0.05). The 1-year, 3-year and 5-year survival rates of the experimental group were higher than those of the control group (P<0.05). 【Conclusion】Ginsenoside Rg3 combined with neoadjuvant chemoradiotherapy in patients with gastric cancer shows higher RO resection rate. It can significantly lower the expression of VEGF and MTA1, improve body immunity, reduce recurrence rate, and increase the survival rate of patients. The effect is significant in clinical application.
李祥伟;张正元;周光荣. 人参皂苷Rg3联合新辅助放化疗对胃癌组织VEGF、MTA1蛋白表达及预后的影响[J]. 医学临床研究, 2017, 34(3): 459-461.
LI Xiang-wei, ZHANG Zheng-yuan, ZHOU Guang-rong. Effect of Ginsenoside Rg3 Combined with Neoadjuvant Chemoradiotherapy on the Expression of VEGF and MTA1 Protein in Gastric Cancer Tissues and Prognosis. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 459-461.
2017, Vol. 34 
