Abstract：【Objective】To investigate urinary VEGF level and related factors in newly diagnosed type 2 diabetes mellitus (T2DM) patients. 【Methods】The urinary VEGF level was measured by enzymelinked immunosorbent assay (ELISA) in 71 patients with newly diagnosed T2DM. The urinary VEGF level and related biochemical indicators were compared between newly diagnosed T2DM patients with normal albuinuria (n=41) and microalbuminuria (n=32). The related factors for the urinary VEGF level in newly diagnosed T2DM patients with analyzed by Pearson and Liner linear regression analysis. 【Results】Compared with newly diagnosed T2DM patients with normal albuinuria, fasting blood glucose, glycated hemoglobin (HbA1c), total cholesterol, lowdensity lipoprotein cholesterol, serum uric acid and urinary VEGF level were significantly higher in patients with microalbuminuria. In newly diagnosed T2DM, the urinary VEGF level was positively related with fasting blood glucose, glycated hemoglobin(HbA1c), lowdensity lipoprotein cholesterol, serum uric acid and urine albuminuria. HbA1c and urine albuminuria were independent factors for urinary VEGF level in newly diagnosed T2DM patients (Beta=18.4，0.626；P=0.017，0.010 ). 【Conclusion】The urinary VEGF level is directly related with HbA1c and urine albuminuria in newly diagnosed T2DM patients. The urinary VEGF level could be a potential marker for renal damage in newly diagnosed T2DM.
2016, Vol. 33 
