Effect of Adjuvant Therapy with Compound Hongdoushan Capsules on Peripheral Blood T Lymphocyte Subsets and Vascular Endothelial Growth Factors in Patients with Ovarian Cancer Treated with Chemotherapy
YU Jing, YE Lin-yan
Department of Pharmacy, Mianyang Central Hospital,Mianyang, Sichuan, 621000
摘要【目的】 探讨复方红豆杉胶囊辅助治疗对卵巢癌术后化疗患者外周血T淋巴细胞亚群、血管内皮生长因子(VEGF)的影响。【方法】选择2012年3月至2016年4月在本院诊治的卵巢癌患者88例,按随机数表法分为对照组与观察组,每组44例。对照组接受卵巢癌根治术,术后配合化疗,观察组在对照组基础上加用复方红豆杉胶囊辅助治疗。比较两组疗效及治疗前后外周血T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)、VEGF、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平,统计两组毒副反应发生率。【结果】①观察组总缓解率高于对照组( P <0.05);②治疗前,两组CD3+、CD4+、CD8+、CD4+/CD8+、IL-6、IL-8、TNF-α、VEGF水平比较差异无统计学意义( P >0.05),治疗后,观察组CD3+、CD4+、CD4+/CD8+水平高于对照组, IL-6、IL-8、TNF-α、VEGF水平均低于对照组( P <0.05);③观察组Ⅰ~Ⅱ级胃肠道反应、血尿、白细胞计数减少发生率低于对照组( P <0.05)。【结论】在卵巢癌术后化疗中辅助应用复方红豆杉胶囊,可优化化疗效果,提高机体免疫功能,减轻毒副反应,值得临床推广应用。
Abstract:【Objective】To investigate the effect of adjuvant therapy with Compound Hongdoushan Capsules on peripheral blood T lymphocyte subsets and vascular endothelial growth factors (VEGF) in patients with ovarian cancer treated by chemotherapy after operation. 【Methods】 A total of 88 cases of patients with ovarian cancer treated in our hospital during March 2012 to April 2016 were selected and randomly divided into the control group and the observation group by the random number table method, with 44 cases in each group. Both groups were treated with radical resection of ovarian cancer combined with postoperative chemotherapy, and patients in the observation group were additionally treated with Compound Hongdoushan Capsules. The therapeutic effects were compared between the two groups, and changes of levels of T lymphocyte subsets such as CD3+, CD4+, CD8+, and CD4+/CD8+ in peripheral blood were detected before and after treatment. The changes of VEGF, interleukin -6 (IL-6), interleukin -8 (IL-8), and tumor necrosis factor α (TNF-α) levels were determined before and after treatment, and the incidence of side effects in the two groups was statistically analyzed. 【Results】 The total remission rate of the observation group was higher than that of the control group ( P < 0.05). Before treatment, there was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/CD8+, IL-6, IL-8, TNF-α, and VEGF between the two groups ( P > 0.05). After treatment, the levels of CD3+, CD4+, and CD4+/CD8+ in the observation group were higher than those in the control group, and the levels of IL-6, IL-8, TNF-α and VEGF in the observation group were lower than those in the control group ( P < 0.05). The incidence rates of grade Ⅰ~Ⅱ gastrointestinal reactions, hematuria, and WBC count decline in the observation group were lower than those in the control group ( P < 0.05). 【Conclusion】The adjuvant therapy with Compound Hongdoushan Capsules has synergistic effects in the chemotherapy of ovarian cancer. It can optimize the effects of chemotherapy, improve the immune function and reduce the side effects.
敬渝, 叶霖燕. 复方红豆杉胶囊辅助治疗对卵巢癌术后化疗患者外周血T淋巴细胞亚群、血管内皮生长因子的影响[J]. 医学临床研究, 2018, 35(7): 1265-1267.
YU Jing, YE Lin-yan. Effect of Adjuvant Therapy with Compound Hongdoushan Capsules on Peripheral Blood T Lymphocyte Subsets and Vascular Endothelial Growth Factors in Patients with Ovarian Cancer Treated with Chemotherapy. JOURNAL OF CLINICAL RESEARCH, 2018, 35(7): 1265-1267.