Abstract：【Objective】To investigate the efficacy of voglibose capsule combined with sitagliptin phosphate tablets in the treatment of elderly patients with type 2 diabetes mellitus (T2DM). 【Methods】A total of 186 patients with T2DM admitted to our hospital from February 2016 to May 2018 were enrolled. Patients were divided into the observation group and the control group by the random number table method, with 93 cases in each group. The control group received oral sitagliptin phosphate tablets and the observation group received oral voglibose capsules and sitagliptin phosphate tablets. The levels of fasting blood glucose (FPG) and 2 hours postprandial blood glucose (2hPG) were measured by glucose oxidase method before and after treatment, and the levels of HbA1c were analyzed by high performance liquid chromatography. The average daily blood glucose fluctuation (MAGE) and blood glucose standard deviation (SD) were calculated according to the blood glucose map in the Accu-Chek Performa Roche blood glucose meter, and the incidence of hypoglycemia was recorded. The incidence of adverse reactions in the two groups during treatment was recorded. 【Results】 Before treatment, there were no significant differences in the levels of FPG, 2 h PG and HbA1c between the two groups (P>0.05). After treatment, the levels of FPG, 2 h PG and HbA1c were significantly lower in the two groups (P<0.05). The values in the observation group were remarkably lower than those in the control group (P<0.05). The incidence of daily mean MAGE, SD and hypoglycemia in the observation group were significantly lower than those in the control group (P<0.05). The incidence of adverse reactions in the observation group and the control group were 9.68% and 10.75%, respectively. There was no significant difference between the two groups (P>0.05). 【Conclusion】 Voglibose capsule combined with sitagliptin phosphate tablets in the treatment of T2DM is better than single sitagliptin phosphate tablets. It shows that the blood sugar fluctuation is smaller, the incidence of hypoglycemia is lower, and it is safe and reliable.
徐伟, 罗涌, 何艳. 伏格列波糖胶囊联合磷酸西格列汀片治疗老年性2型糖尿病的疗效观察[J]. 医学临床研究, 2019, 36(7): 1252-1254.
XU Wei, LUO Yong, HE Yan. Therapeutic Effect of Voglibose Capsule Combined with Sitagliptin Phosphate Tablets in Elderly Patients with Type 2 Diabetes. JOURNAL OF CLINICAL RESEARCH, 2019, 36(7): 1252-1254.
2019, Vol. 36 
