Effect of Continuous Positive Airway Pressure on Serum Insulin-like Growth Factor-1 and Amylin in Patients with Severe Obstructive Sleep Apnea Hypopnea Syndrome
QIN Ran-Ran, LUO Hong
Department of Respiratory Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011
Abstract：【Objective】To investigate the effects of continuous positive airway pressure (CPAP) on serum insulin-like growth factor-1 (IGF-1) and amylin in adult patients with obstructive sleep apnea hypopnea syndrome (OSAHS). 【Methods】A total of 118 patients with OSAHS diagnosed by polysomnography (PSG) were selected in the observation group, which were further divided into heavy, medium and light subgroups according to apnea hypopnea index (AHI). In the same time period, 55 healthy people without OSAHS were enrolled in the control group. Serum IGF-1 and amylin levels were measured by ELISA. Among OSAHS patients, 30 severe cases were followed up for 3 months of CPAP treatment. After half a year, IGF-1 and amylin were retested.【Results】With the severity of OSAHS, the patient's serum IGF-1 gradually decreased, and the level of amylin gradually increased (F=37.732,18.744;P<0.01). However, there was no difference between the mild group and the control group (P>0.05). Levels of serum IGF-1 and amylin levels were not correlated with BMI and age(P＞0.05). There was a negative correlation between amylin and nighttime minimum oxygen saturation (LSaO2) and a positive correlation with AHI(P＜0.01). In addition, there was a positive correlation between serum IGF-1 and LSaO2, and negatively correlated with AHI (P＜0.01). After 3 months of CPAP treatment, serum IGF-1 level in 36 severe OSAHS patients was higher than before treatment, and amylin level was lower than before treatment. The difference was statistically significant (P＜0.05). After half a year of treatment, serum IGF-1 was 56.61±5.46 ng/mL, which showed significant decrease, and amylin was 26.87±2.84 ng/mL, which showed significant increase (P<0.01).【Conclusion】 OSAHS patients have a decrease in serum IGF-1 level and an increase in amylin level, which may be associated with concurrent insulin resistance. CPAP treatment can significantly increase serum IGF-1 and decrease amylin levels in half a year. It is speculated that monitoring serum IGF-1 and amylin levels can evaluate the efficacy.
秦冉冉, 罗红. CPAP对成人重度OSAHS患者血清胰岛素样生长因子-1、胰淀素的影响[J]. 医学临床研究, 2019, 36(3): 430-432.
QIN Ran-Ran, LUO Hong. Effect of Continuous Positive Airway Pressure on Serum Insulin-like Growth Factor-1 and Amylin in Patients with Severe Obstructive Sleep Apnea Hypopnea Syndrome. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 430-432.
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2019, Vol. 36 
