Abstract：【Objective】 The clinical efficacy and safety of human serum albumin for patients with cirrhosis and ascites were systematically assessed. 【Methods】 We searched Medline,Embase,Cochrane Library,Pubmed,China Biomedical Literature (CBM),WanFang Datebase,VIP and Chinese Journal Full-text database (CNKI). The search deadline from above databases was May 2018. A randomized controlled trial of long-term infusion of human albumin combined with diuretics (the experimental group) and separate diuretics (the control group) in patients with cirrhosis and ascites was performed. Two reviewers were independently involved in the studies using RevMan5.2 software, performed quality assessment, extracted the data, evaluated the risk of bias, and made the conclusions. 【Results】 A total of 803 patients with 5 articles were included. Meta-analysis showed that the overall survival rate was improved in the experimental group compared with the control group [HR=0.60,95%CI(0.44,0.83),P=0.002]. Data also showed the experimental group significantly reduced the incidence of complications [RR=0.35,95%CI(0.18,0.69),P=0.002], re-admission rate [RR=0.23,95%CI(0.13,0.43),P<0.001] and ascites recurrence rate [RR=0.17,95%CI(0.07,0.42),P<0.001]. There were no significant differences between the two groups in the incidence of serious adverse reactions and human serum albumin related adverse events. 【Conclusion】 Long-term infusion of human serum albumin for patients with cirrhosis and ascites can increase the overall survival and reduce the incidence of complications and re-admissions. It does not increase the incidence of adverse reactions.
陈丽, 谭波宇, 韦鸿雁, 邓楠. 长期应用人血白蛋白治疗肝硬化腹水疗效的Meta分析[J]. 医学临床研究, 2018, 35(12): 2338-2342.
CHEN Li, TAN Bo-yu, WEI Hong-yan, et al. Meta-Analysis of the Efficacy of Long-term Albumin Infusion for Patients with Cirrhosis and Ascites. JOURNAL OF CLINICAL RESEARCH, 2018, 35(12): 2338-2342.
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2018, Vol. 35 
