Abstract：【Objective】To evaluate the role of chemotherapy and targeted drug treatment in advanced biliary tract cancer (BTC). 【Methods】By searching MEDLINE, EMBASE and other domestic and foreign databases, a randomized controlled trial (RCT) for advanced BTC was conducted. The patients in the observation group were treated with chemotherapy combined with targeted drugs, while the patients in the control group received chemotherapy alone. Meta analysis on the objectiv remission rates, median overall survival (OS), progression free survival (PFS), and adverse events was performed in both groups. 【Results】A total of 8 RCTs were enrolled, including 1052 patients in total. There were 549 patients in the observation group and 503 patients in the control group. The objective remission rate in the observation group was significantly higher than that in the control group (P<0.05). However, there were no significant differences in OS, the first half year of PFS and one year PFS between the two groups (P>0.05). The incidence of nausea / vomiting and bone marrow toxicity was not significantly different between the two groups (P>0.05). The incidence of skin toxicity and diarrhea in the observation group was higher than that in the control group (P<0.05). 【Conclusion】Based on the latest RCTs, meta-analysis shows that chemotherapy combined with targeted therapy can improve the objective response rate of late BTC. However, it does not have significant survival benefits.
王晓华, 廖佳, 杨帆, 周强. 单纯化疗与化疗联合靶向药物对晚期胆道系统肿瘤的疗效比较的Meta分析[J]. 医学临床研究, 2018, 35(10): 1895-1898.
WANG Xiao-hua, LIAO Jia, YANG Fan, et al. Meta-analysis of the Efficacy of Chemotherapy Alone vs. Chemotherapy Combined with Targeted Drugs for Advanced Biliary Tract Cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(10): 1895-1898.
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2018, Vol. 35 
