Abstract:【Objective】To investigate the application effect of Ischemia Modified Albumin inspection in patients with acute chest pain. 【Methods】 100 cases of patients with acute chest pain in 3 h admitted in our hospital from Feb 2014 to July 2015 were selected and divided into ischemic chest pain group (59 cases) and nonischemic chest pain group (41 cases). The Ischemic chest pain group was further divided into unstable angina group (39 cases) and acute myocardial infarction group (20 cases). The venous blood was collected at the instant, 3 h and 24 h after admission. Creatine kinase isoenzyme (CKMB), cardiac troponin I (cTnI) and IMA were determined. 【Results】At the instant and 3 h after admission, the IMA of the ischemic chest pain group was significantly higher than that of the nonischemic chest pain group (P<0.05), while there was no significant difference between cTnI and CKMB level (P>0.05). At 24 h after admission, there was no significant difference in IMA between the ischemic chest pain group and the nonischemic chest pain group (P>0.05); cTnI and CKMB of the ischemic chest pain group were significantly higher than those of the nonischemic chest pain group (P<0.05). At the instant, 3 h and 24 h after admission , IMA level between the unstable angina group and the acute myocardial infarction group was not statistically significant (P>0.05). 【Conclusion】 Ischemia Modified Albumin is a sensitive index for early diagnosing ischemic chest pain and nonischemic chest pain, but could not diagnose unstable angina and acute myocardial infarction.