Abstract：【Objective】 To investigate the expression and clinical significance of total cholesterol (TC), high-sensitivity C-reactive protein (hs-CRP) and apolipoprotein B (ApoB) in the serum of type Ⅱ diabetes mellitus (T2DM) patients with subclinical hypothyroidism (SCH).【Methods】 From April 2015 to January 2018, 140 patients with T2DM combined with SCH were treated in our hospital (observation group) and 140 T2DM patients with normal thyroid stimulating hormone (TSH) were selected as control group. Age, sex ratio, blood lipid and serum hs-CRP levels were compared between the two groups, and the correlation between the above indexes and thyroid hormone level was analyzed.【Results】 The average age, the proportion of female and the level of serum TC,LDL-C,ApoB,hs-CRP of the patients in the observation group were significantly higher than those in the control group. Multivariate Logistic regression analysis showed that the increase of TC,LDL-C, ApoB, hs-CRP,TSH level was an independent risk factor for SCH in T2DM patients (mean P<0.05).【Conclusion】 Compared with the patients with T2DM alone, the level of lipid metabolism is abnormal in patients with T2DM combined with SCH, and the inflammatory reaction is involved in the formation of vascular lesions. Hs-CRP can be used as an effective index for monitoring the occurrence of SCH in patients with T2DM.
钱露, 刘萍. TC、ApoB、hs-CRP水平在T2DM合并亚临床甲状腺功能减退患者血清中的表达水平及临床意义[J]. 医学临床研究, 2018, 35(12): 2343-2345.
QIAN Lu, LIU Ping. Study on the Expression of TC、ApoB and Hs-CRP in Patients with Subclinical Hypothyroidism of T2DM. JOURNAL OF CLINICAL RESEARCH, 2018, 35(12): 2343-2345.
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2018, Vol. 35 
