Abstract:【Objective】 To investigate the effects of analgesia and quality of life in patients with cancer pain through acupoint introduction of lappaconitone by ultrasonic pulse therapy instrument . 【Methods】 A total of 98 patients with advanced stage tumors admitted to our hospital were divided into two groups. Patients (n=48) in the control group received standardized treatment for cancer pain , and patients (n=50) in the observation group were treated with ultrasound-guided analgesia on the basis of routine treatment. Both groups received continuous treatment for 7 days . Analgesic effect and quality of life between the two groups were compared. 【Results】 After treatment, the NRS scores (number rating scale) of the two groups were lower than those before treatment(P<0.05) , and the NRS scores in the observation group were significantly lower than in the control group (P<0.05) . The total effective rate of pain relief in the observation group was 90.00% (45/50), which was significantly higher than that in the control group 68.75%(33/48,P<0.05). Before treatment , there was no significant difference in life quality measurement scale (WHOQOL-BREF scores) between the two groups (P>0.05 ) . After treatment, both groups had higher scores in terms of subjective feeling of health condition, quality of life, physiological, psychological, environmental and social relations (P<0.05) . Compared to the control group, the scores of subjective feeling of health condition , physiological and psychological status in the observation group was better (P<0.05 ) . There was no significant difference in subjective feeling of life quality, environmental and social relations between the two groups (P>0.05 ) . 【Conclusion】 The introduction of lappaconitone by ultrasonic pulse therapy can significantly reduce the pain level of cancer patient and improve the pain relief rate and quality of life in patients with cancer pain
刘伟, 李玉芹, 穆蓉, 田丽梅, 张莉, 刘柏琳, 王秀义, 刘建军, 陈连锁. 经超声脉冲理疗仪穴位导入高乌甲素对癌痛患者镇痛效果及生活质量的影响[J]. 医学临床研究, 2018, 35(12): 2304-2306.
LIU Wei, LI Yu-qin, MU Rong, et al. Effect of Introduction of Lappaconitone on Analgesia and Quality of Life in Patients with Cancer Pain by Ultrasonic Pulse Therapy Instrument. JOURNAL OF CLINICAL RESEARCH, 2018, 35(12): 2304-2306.
[1] Andreassen Jaatun EA,Hjermstad MJ,Gundersen OE,et al.Development and testing of a computerized pain body map in patients with advanced cancer[J].J Pain Symptom Manage,2014 , 47 ( 1 ) :45-56. [2] Cavalcanti IL,Carvalho CG,Musauer M,et al . Efficacy and tolerability of controlled - release oxycodone for acute postoperative pain after head and neck cancer surgery : Prospective , Observational , open study : 14API-2[J].Rev Art,2013,30:204-205. [3] 盛良翮,徐萌,徐立群,等.高乌甲素对非小细胞肺癌体外杀伤作用及其分子机制[J].中药材,2014,37(5):840-843. [4] 孙晶,李元涛.氢溴酸高乌甲素复合瑞芬太尼自控静脉镇痛在分娩镇痛潜伏期中的应用及对子宫收缩的影响[J].中国妇幼保健,2017,32(22):5520-5524. [5] Chang GX , Ling JZ , Guo W , et al . Clinical observation of different doses of lappaconitne combined with morphinesulfate sustained-release tablets for the treatment of elderly patients with moderate to severe cancer pain[J].Prac Geriatr,2017 , 31 ( 2 ): 146-149. [6] 张磊,刘啸,王艳军,等.高乌甲素联合奥施康定治疗中重度癌痛的临床观察[J].现代肿瘤医学,2016,24(18):2961-2964. [7] Meserve JR , Kaye AD , Prabhakar A , et al . The role of analgsics in cancer propagation[J].Best Pract Res Clin Anaesthesiol,2014 , 28 ( 2 ) : 139-151. [8] 王平.微量泵皮下自控镇痛对晚期癌痛患者疼痛控制及生活质量的影响[J].肿瘤学杂志,2016,22(10):861-863. [9] 常国祥,凌金祖,郭伟,等.不同剂量高乌甲素联合硫酸吗啡缓释片治疗老年中重度癌痛的临床观察[J].实用老年医学,2017,31(2):146-149.