Abstract:【Objective】To evaluate the clinical application value of sevoflurane inhalation anesthesia in fast-track infant operation. 【Methods】A total of 68 children undergoing fast-track infant operation were divided into two groups by odd and even numbers, with 34 cases in each group. The observation group was given mask inhalation of sevoflurane for induction while the control group was given ketamine anesthesia induction. The anesthesia induction time, postoperative recovery time, mean arterial pressure (MAP), heart rate (HR), SpO2 and the incidence of adverse reactions were recorded and compared. 【Results】The anesthesia induction time and postoperative recovery time of the observation group were significantly shorter than those of the control group (P<0.05). After the induction, MAP and HR of the observation group were significantly lower than those of the control group (P<0.05). The incidence rates of nausea and vomiting, increased secretions, laryngeal spasm in the observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】Sevoflurane inhalation anesthesia has the advantages of short induction time, quick postoperative recovery and little effect on hemodynamics in fast-track infant operation. It is safe and worthy of clinical use.